Furosemide (Lasix) Not in CT Protocols

Question 1

Furosemide (Lasix)
Classification

Answer 1

Loop Diuretic

Question 2

Furosemide (Lasix)
Mechanism of Action

Answer 2

-Enhances vasular prostaglandin synthesis which decreases intracellular calcium and vascular SMC relaxation which causes venous dilation and reduced preload
-Binds to chloride binding site on Na/2Cl/K+ cotransporter found on the luminal surface of the thick ascending limb on loop of Henle which inhibits sodium and chloride reabsorption in the kidneys, thus impacting the osmotic gradient and reducing water reabsorption in the decending limb

Question 3

Furosemide (Lasix)
Onset of Action

Answer 3

5-10 min vasodilation
5-30 min diuresis

Question 4

Furosemide (Lasix)
Peak Effects

Answer 4

30 min vasodilation
20-60 min diuresis

Question 5

Furosemide (Lasix)
Duration of Effect

Answer 5

2 hr vasodilation
6 hr diuresis

Question 6

Furosemide (Lasix)
Half-life

Answer 6

30 min

Question 7

Furosemide (Lasix)
Indications/Field Use

Answer 7

Acute pulmonary edema secondary to CHF

Question 8

Furosemide (Lasix)
Contraindications

Answer 8

Pregnancy

Question 9

Furosemide (Lasix)
Side Effect/Adverse Reactions

Answer 9

Ha
Dizziness
Hypotension
Volume depletion
Potassium depletion
Dysrhythmias
Dehydration
Diarrhea
N/V

Question 10

Furosemide (Lasix)
Adult Dose

Answer 10

40mg slow IV/IO
If pt takes Lasix including today give thier dose
If pt takes Lasix but didn’t take today give double

Question 11

Furosemide (Lasix)
Pedi Dose

Answer 11

0.5-1mg/kg slow IVP (not for children under 12)

Question 12

Furosemide (Lasix)
Precautions

Answer 12

Protect from light
Caution with renal failure and sulfa allergies

Question 13

Furosemide (Lasix)
Drug-Drug Interactions

Answer 13

-May cause additive effects and/or electrolyte imbalance if given with other diuretic
-NSAIDs may antagonize effects of Lasix