Methods of Labeling

Question 1

Labeling of MDP is done by adding…

Answer 1

SnCl2 or SnF2

Question 2

what does adding stannous ion to Tc do?

Answer 2

reduce free Tc and helps improve labeling even after initial donation of electrons

Question 3

what do we add to prevent free Tc building up everytime we introduce O2 via needle poke?

Answer 3

1-2 mg of absorbic acid (antioxidant)

Question 4

when does MDP kit expire?

Answer 4

6 hours post making

Question 5

what to expect for adverse rxn to MDP?

Answer 5

occurr within 1-2 hours. give PYP next time

Question 6

how is MDP excreted?

Answer 6

urinary

Question 7

MAA is labeled by heating a mixture of what

Answer 7

mild acidifier, stannous chloride, and human serum albumin to create MAA particles

Question 8

what distribution size or particles filtered to be

Answer 8

10-90 um

Question 9

what particle size can MAA not be greater than

Answer 9

150um

Question 10

how quickly is MAA cleared from the blood

Answer 10

almost immediately as it passes through the heart and removed by lung immediately (if shown in brain and kidneys then a shunt)

Question 11

half life for removal from lungs of MAA

Answer 11

1.5-6 hours

Question 12

how are particles cleared from the lungds

Answer 12

the mechanical breakdown as respiration occurs and the macrophages phagocytize them (reduce particle count to not overwork macrophages)

Question 13

MAA dose

Answer 13

1-5 mCI Tc99-MAA

Question 14

recommened particle count for MAA

Answer 14

200,000-700,000 which avg 350,000

Question 15

too many particles can cause in pt with what disease

Answer 15

right cardiac failure in pt with pulmonary hypertension

Question 16

to minmize risk of right cardiac failure what particle count should you use

Answer 16

100,000-200,000

Question 17

3 ways to reduce particle count

Answer 17

reduce radioactivity dose reduces particles by volume, incr radioactivity of concentration per particles, reduce number of particles in vial by adding saline and removing

Question 18

what temp should MAA kit be stored at and why

Answer 18

2-8 degrees celcius to prevent microorganism growth

Question 19

as more tc decays and time passes what is true about the amount of particles

Answer 19

more particles have to be used per dose to acquire same activity needed

Question 20

expiration of MAA

Answer 20

12 hours but 6 hours at froedtert

Question 21

incubation time of MAA

Answer 21

15 minutes