Methods of Labeling Flashcards
Labeling of MDP is done by adding…
SnCl2 or SnF2
what does adding stannous ion to Tc do?
reduce free Tc and helps improve labeling even after initial donation of electrons
what do we add to prevent free Tc building up everytime we introduce O2 via needle poke?
1-2 mg of absorbic acid (antioxidant)
when does MDP kit expire?
6 hours post making
what to expect for adverse rxn to MDP?
occurr within 1-2 hours. give PYP next time
how is MDP excreted?
urinary
MAA is labeled by heating a mixture of what
mild acidifier, stannous chloride, and human serum albumin to create MAA particles
what distribution size or particles filtered to be
10-90 um
what particle size can MAA not be greater than
150um
how quickly is MAA cleared from the blood
almost immediately as it passes through the heart and removed by lung immediately (if shown in brain and kidneys then a shunt)
half life for removal from lungs of MAA
1.5-6 hours
how are particles cleared from the lungds
the mechanical breakdown as respiration occurs and the macrophages phagocytize them (reduce particle count to not overwork macrophages)
MAA dose
1-5 mCI Tc99-MAA
recommened particle count for MAA
200,000-700,000 which avg 350,000
too many particles can cause in pt with what disease
right cardiac failure in pt with pulmonary hypertension
to minmize risk of right cardiac failure what particle count should you use
100,000-200,000
3 ways to reduce particle count
reduce radioactivity dose reduces particles by volume, incr radioactivity of concentration per particles, reduce number of particles in vial by adding saline and removing
what temp should MAA kit be stored at and why
2-8 degrees celcius to prevent microorganism growth
as more tc decays and time passes what is true about the amount of particles
more particles have to be used per dose to acquire same activity needed
expiration of MAA
12 hours but 6 hours at froedtert
incubation time of MAA
15 minutes
