Bone Therapeutics Flashcards
how do bone therapies localize?
ion exchange same as dx
-intent to deliver small amount of radiation to metabolically active area repping mets
Sr-89 is in same periodic group as what element? what does this say about Sr?
Ca so it has same physiological uptake mechanism and chemical properties.
half life of Sr-89
50.5 d
energy and mode of decay SR 89
1.46 Mev and beta emissionS
sR-89 UPTAKE speed and turnover time?
rapid and retained in bone 14 d
excretion of Sr-89
2/3 urinary and 1/3 fecal
Sr-89 dose
4 mCi
how is Sr-89 given
IV and be careeful of administration bc strontium salts will damage skin really bad
precautions with pt treated w Sr-89
no caution to others bc pure beta
Sr-89 chloride for injection brand name?
Metastron
Sm-153 drug name and chemical name (EDTMP)
Samrium Lexidronam and ethylenediaminetetramethylenephosphonate acid
Sm-153 EDTMP is a ________that has similar properties to _____
chelate, Tc99m phosphonate bone imaging agents
Sm-153 half life
46.3 hrs
energy and decay of Sm-153
beta and gamma (103 keV)
sm 153percentage of uptake in skeleton varies depending on what
extent of mets
sm153 avg uptake percent is
65% of injected dose
Sm-153 excretion is
urinary
sm153 what percent of dose is excreted after 6 hours
34.5 %
how to minimize bladder irritation in Sm153 pts
hydrate prior and urinate often during first 24 hour
sm 153 dose
1 mCi/kg of body weight
sm153 admin
iv with a slow infusion
how is Sm153 supplied
2-3 mL vials that are frozen with 100-150 mCi activity
expiration of sm153
once thawed-8 hrs
48 hours post cal time
commercial product name of Sm153 EDTMP
quadramet
