Metastatic

Question 1

What is first line chemotherapy for metastatic H&N?

Answer 1

Carbo AUC5, capecitabine 750mg/m2 BD D1-14 q21d

Oral cavity can give cis/5fu/cetuximab

Question 2

What is 2nd line chemotherapy?

Answer 2

Nivolumab 3mg/kg every 2/52. Stopped at 2y
If PD <6m from last platinum based chemo
MOS 7.7m. 20% 18 month survival

Question 3

What is 3rd line chemotherapy?

Answer 3

Docetaxel