General Flashcards
1
Q
What drug can be used with radical XRT in patients unfit for cisplatin?
A
Cetuximab
Bonner trial - cetuximab & XRt v XRT alone. OS 49m v 29m
2
Q
What are the main SE of cetuximab?
A
Hypersensitivity Skin rash Low Mg Headache after C1 Transient hepatic enzyme elevation Cough/dyspnoea Conjunctivitis
3
Q
What is the dose of cetuximab in the concurrent setting?
A
400mg/m2 loading (1week prior to XRT), then 250mg/m2 weekly