Metastases Flashcards
What tumours commonly cause bone mets?
Prostate
Breast
Lung
Most common sites of bone mets? Detection method?
Spine Pelvis Ribs Skull Long bones
Isotope bone scan
What are features of bony mets?
Pathological fractures
Bone pain
Hypercalcaemia
Raised ALP
FAPH
What Ix for metastatic disease of unknown primary?
FBC U&E LFT Calcium Urinalysis LDH
CXR
CT CAP
AFP and hCG
What Ix if lytic bone lesions? Men? Women with peritoneal malignancy of ascites? Germ cell tumour?
Myeloma screen (if lytic bone lesions)
Endoscopy (directed towards symptoms)
PSA (men)
CA 125 (women with peritoneal malignancy or ascites)
Testicular US (in men with germ cell tumours)
Mammography (in women with clinical or pathological features compatible with breast cancer)
What is PET? Uses?
Nuclear imaging which uses fluorodeoxyglucose as radiotracer
Allows 3D image of metabolic activity generated using glucose uptake
Combined with CT to see where metabolically active lesions are
Evaluating primary and possible mets
Presentation of metastatic spinal cord compression? Ix?
New onset nocturnal back pain
MRI spine within 24 hours