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CC 2 lab group quiz > Metabolism & Secretion Thyroid Cont'd > Flashcards

Metabolism & Secretion Thyroid Cont'd Flashcards

1
Q

How many days does T4 is synthesized?

A

from direct TG secretion
(6-7 days)

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2
Q

Where does most Plasma T3 derived?

A
  • Extra-thyroidal deiodination
  • Liver/kidney
  • Peripheral tissues
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3
Q

T4 accounts 80% of plasma T3

A

Extra-thyroidal deiodination

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4
Q

deiodinate T4

A

Liver/kidney

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5
Q

Peripheral tissue

A

T4 → T3/rT3

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6
Q

more active

A

T3

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7
Q

inactive

A

rT3

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8
Q

TRUE or FALSE: T3 test is useful in diagnosing hypothyroidism

A

FALSE; it is not useful in diagnosing hypothyroidism because levels
are not reduced until it becomes severe

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9
Q

Enumerate three process from which TH is metabolized:

A

– deiodination, deamination, conjugation (by glucuronic acid)

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10
Q

complete the process below:

Conjugated → ________ → Intestine → ________

A

Conjugated → Bile duct → Intestine → excreted

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11
Q

Give what is/are asked:

What is/are inhibitory substances for TH synthesis:

A
  • Glucocorticoids
  • Dopamine
  • Propanolol
  • Lithium
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12
Q

inhibits TSH → decrease T4 and T3

A

Glucocorticoids’

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13
Q

inhibits TSH

A

Dopamine

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14
Q

inhibit conversion of T4 to T3

A

Propanolol

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15
Q

alter Tg structure, inhibit iodotyrosine coupling, inhibit thyroid hormones

A

Lithium

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16
Q

it is considered aas the 3rd most circulating thyroid hormone

A

rT3

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17
Q

what does the rT3 remove?

A

it removes 1 iodine from the inner ring of T4

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18
Q

Discuss the Hypothalamic-pituitary-thyroid axis

A

Low TH = increase TRH & TSH

-Increase T3, T4 = decrease TRH & TSH

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19
Q

Half-life of T4 metabolism

A

4 hours

19
Q

rT3 is elevated in which condition?

A

rT3 is elevated in patients with euthyroid sick syndrome

it is used to assess borderline or conflicting laboratory results

20
Q

enumerate the 4 isoforms of T3 receptors:

A

α1 – present in most tissues
α2 – inhibitory of thyroid hormones
β1 – works with α1
β2 – in pituitary, for negative feedback

21
Q

Serum iodide

A

High = transport inhibited, high DIT, T4
Low = more absorbed, high MIT, T3

22
Q

other name for Triidothyronine (T3)

A

3, 5, 3’ TriIodothyronine

23
Q

TRUE or FALSE: T4 it has the most hormonal activity

A

FALSE: it is T3

24
Q

TRUE or FALSE: T3 indicator of recovery or recurrence of hyperthyroidism

A

TRUE

25
Q

TRUE or FALSE: T4 is 1st seen in hyperthyroidism

A

FALSE; it is T3

26
Q

How do we measure T3 levels?

A

via competitive immunoassay

27
Q

What is the physiologically active form of T3?

A

FT3

28
Q

what is the other name for Tetraiodothyronine (T4)

A

“3,5, 3’, 5’ Tetraiodothyronine”
“Thyroxine”

29
Q

TRUE or FALSE: T4 is the principal secretory product

A

TRUE

30
Q

TRUE or FALSE: T3 is the MAJOR fraction of Organic iodine Prohormone of T3

A

FALSE; it is T4

31
Q

it is and indicator for thyroid secretory rate

A

increase T4

32
Q

How do we measure T4 levels?

A

Immunoassay after hormone separated from protein

33
Q

Physiologically active form of T4

A

FT4

34
Q

conversion factor for T4

A

12.9

35
Q

these are agents that causes goiter, increases TSH

A

Goitrogens

36
Q

a type of Goiter that does not define functional state

A

Thyromegaly

37
Q

Enumerate the types of Thyromegaly

A
  • Hyperthyroidism (Toxic)
  • Hypothyroidism (non-toxic)
  • Euthyroid (Non-toxic)
38
Q

Classifications of goiter:
Stage 0
Stage 1a
Stage 1b
Stage 2
Stage 3

A
  • No!
    – palpable, not visible
    – palpable, visible if neck is extended
    – visible (even neck not extended)
    – very large
39
Q
  • Most important test for thyroid function monitoring
  • Used for monitoring and to adjust thyroid hormone replacement therapy
A

Thyroid Stimulating Hormone determination:

40
Q

Good for differentiating Primary hypothyroidism and Secondary hypothyroidism and also best for detection of
primary thyroid disorder

A

Thyroid Stimulating Hormone determination:

41
Q

Used as marker for Thyroid cancer (post-operative or monitoring metastatic/recurrence)

A

Thyroglobulin test

42
Q

what does thyroglobulin differentiates?

A

sub-acute thyroiditis (high) from thyrotoxicosis factitia (low)

43
Q

These are the lab methods employed for Thyroglobulin tests

A
  • ELISA,
  • RIA,
  • IRMA,
    =Immunochemiluminescent assay
44
Q

enumerate the conditions for Thyroglobulin test:

Increase:
Decrease:

A
  • Thyroid cancer
  • Nodular goiter
  • Hypothyroidism
  • goiterous hypothyroidism
  • thyrotoxicosis factitia
45
Q
A

CC 2 lab group quiz (4 decks)

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