Associated diseases of the Thyroid Flashcards
Hyperthyroidism
increase T3 and T4, decrease TAG level
Hypothyrodism
– decrease T3 and T4, increase TAG level
give the S/S for Hyperthyroidism
- Heat intolerance (increase sweating)
- Emotionally labile
- Tachycardia
- Unexplained weight loss
- Tremors, restlessness, hyperkinesis, anxiety,
irritability - With diarrhea and increase appetite
give the S/S for Hypothyroidism
Cold intolerance (decrease sweating)
- Bradychardia, Fatigue
- Dryness of skin
- Unexplained weight gain, dyspnea, hair loss
- Mental dullness, muscle weakness, constipation
- Yellow discoloration of skin (hypercarotenemia)
- Decrease Na+
, increase CK
Severe: Pleural and Peritoneal effusions, irregular mens,
periorbital edema, myopathy, anemia
Hypothyroidism
Primary Hyperthyroidism
increase T3,T4, FT4, rT3;
decrease TSH,
normal TBG
Increase: aTPO, ATG, TBII, TSI
Secondary Hyperthyroidism
– increase T3, T4, and TSH! (Pituitary problems)
- “TSH” to compare with primary
T3 thyrotoxicosis –
increase T3, normal to decrease T4,
normal FT4
Increase T3 uptake
- Suppressed TSH, NO Signs and symptoms
T4 thyrotoxicosis
increase T4, normal to decrease T3
Grave’s disease
with diffuse toxic goiter
- most common, autoimmune
- 6x more common in girls
- Due to circulating antibodies to TSH receptor
Grave’s disease is associated with?
Exophthalmos and Pritibial Myxedema
Test for Grave’s disease
TSH receptor antibody test
Thyroid is woody/stony hard mass
Riedel’s disease
low TSH, normal FT3 & FT4
- without symptoms
Subclinical hyperthyroidism
painful thyroiditis
- TPO antibody is absent
- Increase Thyroglobulin and ESR
Subacute granulomatous/Subacute non-suppurative
thyroiditis/ De Quervain’s
Primary Hypothyroidism
decrease T3, T4, FT4, rT3; increase TSH, normal
TBG
Normal or increase: aTPO, ATG, TBII
- Normal to decrease: Tg
Secondary Hypothyroidism
decrease T4, decrease TSH (Pituitary no TSH!)
- Decrease T3, FT4
Tertiary Hypothyroidism
decrease T3 and T4 and TSH
Subclinical
normal T3, T4 and FT4; TSH slightly increase
- No signs and symptoms
Other names for Hashimoto’s disease
“chronic autoimmune thyroiditis”
- “Chronic lymphocytic thyroiditis”
Hashimoto’s disease
Common cause of primary hypothyroidism
- Thyroid is replaced by nest of lymphoid tissue
sensitized T-cells bind to cell membrane causing
cell Lysis and inflammatory reaction
- With Goiter
Test for Hashimoto’s disease
Test: TPO antibody = (+) increase TSH
(TPO Ab = tissue destructive disease)
peculiar nonpitting swelling of skin. Skin
infiltrated by mucopolysaccharide
Myxedema
Myxedema
“puffy face” (moon face)
- Weight gain, slow speech
- Thin eyebrows, dry yellow skin
