Metabolism of nutrients after absorption Flashcards

1
Q

Transport to the liver by the

A

hepatic portal system

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2
Q

The liver is a major organ involved in

A

metabolism

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3
Q

The liver has a dual blood supply

A

(a) The nutrient circulation by the hepatic A supplies 400 ml/min and
transports to the liver
[1] Nutrients and oxygen
[2] Lipids absorbed by lymph system
(b) The hepatic portal v. supplies 1100 ml/min and transports all other
absorbed foods to the liver

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4
Q

The blood exits the liver through the ____ which drains 1500 ml/min

A

hepatic v.

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5
Q

Portal obstruction effects

A

(a) Esophageal v.

(b) Inferior mesenteric v.

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6
Q

(a) Esophageal v.

A

[1] A vein located in the esophageal submucosa
[2] Blood flow from the gastric v. through the esophageal v. into the azygous system
[3] The veins are non-elastic and fragile
[4] When portal pressure increases, esophageal veins:
[a] Provide collateral flow from gut to heart
[b] Lead to esophageal bleeding (varices)
[c] Potentially life threatening

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7
Q

Inferior mesenteric v.

A

[1] A vein in the lower large intestine
[2] Blood flows from the inferior mesenteric v. through the hemorrhoidal v. into the hypogastric v.
[3] When portal pressure increases
[a] Provides collateral flow from intestines to heart
[b] Leads to rectal bleeding

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8
Q

Functions of the liver include Manufacture of Bile which is composed of

A

[1] Water
[2] Electrolytes
[3] Bile salts (94% are reabsorbed in ilium)
[4] Bile pigments
[5] Cholesterol
[6] Fats

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9
Q

Functions of the liver include Manufacture of Proteins & AA

A

[1] All of the blood proteins
[2] Liver damage leads to
[a] Decreased plasma proteins
[b] Decreased colloidal OP

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10
Q

Functions of the liver include Storage of

A

(a) Iron
(b) Copper
(c) Glycogen, about 100 g (4 hours worth); 60% of the glucose in an average meal (Note: adipose tissue contains approximately 1 months worth of energy)
(d) Vitamin A
(e) Vitamin D

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11
Q

Functions of the liver include

A

Metabolic center for many activities

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12
Q

Functions of the liver include Detoxification of poisons such as

A

(a) Nitrogenous wastes arising from the deamination of AA forming ammonia which is changed to urea
(b) Alcohol
(c) Other ingested substances

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