Metabolism of nutrients after absorption Flashcards
Transport to the liver by the
hepatic portal system
The liver is a major organ involved in
metabolism
The liver has a dual blood supply
(a) The nutrient circulation by the hepatic A supplies 400 ml/min and
transports to the liver
[1] Nutrients and oxygen
[2] Lipids absorbed by lymph system
(b) The hepatic portal v. supplies 1100 ml/min and transports all other
absorbed foods to the liver
The blood exits the liver through the ____ which drains 1500 ml/min
hepatic v.
Portal obstruction effects
(a) Esophageal v.
(b) Inferior mesenteric v.
(a) Esophageal v.
[1] A vein located in the esophageal submucosa
[2] Blood flow from the gastric v. through the esophageal v. into the azygous system
[3] The veins are non-elastic and fragile
[4] When portal pressure increases, esophageal veins:
[a] Provide collateral flow from gut to heart
[b] Lead to esophageal bleeding (varices)
[c] Potentially life threatening
Inferior mesenteric v.
[1] A vein in the lower large intestine
[2] Blood flows from the inferior mesenteric v. through the hemorrhoidal v. into the hypogastric v.
[3] When portal pressure increases
[a] Provides collateral flow from intestines to heart
[b] Leads to rectal bleeding
Functions of the liver include Manufacture of Bile which is composed of
[1] Water
[2] Electrolytes
[3] Bile salts (94% are reabsorbed in ilium)
[4] Bile pigments
[5] Cholesterol
[6] Fats
Functions of the liver include Manufacture of Proteins & AA
[1] All of the blood proteins
[2] Liver damage leads to
[a] Decreased plasma proteins
[b] Decreased colloidal OP
Functions of the liver include Storage of
(a) Iron
(b) Copper
(c) Glycogen, about 100 g (4 hours worth); 60% of the glucose in an average meal (Note: adipose tissue contains approximately 1 months worth of energy)
(d) Vitamin A
(e) Vitamin D
Functions of the liver include
Metabolic center for many activities
Functions of the liver include Detoxification of poisons such as
(a) Nitrogenous wastes arising from the deamination of AA forming ammonia which is changed to urea
(b) Alcohol
(c) Other ingested substances