Metabolism and Survival Flashcards
catabolic pathways=
break down of complex molecules to simpler ones (energy releasing)
anabolic pathways=
biosynthesis of molecules from building blocks (energy requiring)
Why are reaction rates higher in membranes?
they form surfaces and compartments that allow high concentrations, high surface area to volume ratio allows high concentrations
Fluid mosaic model=
protein pores , pumps and enzymes embedded in phospholipid membranes
Proteins embedded within membrane functions=
- Channel proteins- allow specific molecules to pass through membrane by passive transport
- Protein pumps- binds to specific molecules temp allowing them to cross membrane (active transport)
- Enzymes- catalyse
- Structural support- maintain shape
How do enzymes lower activation energy?
- Bringing substarates to active site
- Orienting substrates correctly
- Removing products from active site (low affinity for active site)
Induced fit=
active site is not rigid, is dynamic and flexible so alters it’s shape to fit substrate
How do enzymes often act?
in groups or multi-enzyme complexes
Rate of metabolism depends on
rate of enzyme activity
Non-competitive inhibition=
the shape of the active site is altered by the
particle binding at allosteric site on the enzyme
Competitive inhibition=
competes with substrate at active site
Feedback inhibtion=
end product binds to allosteric site of first enzymes to alter activity
Respiration=
convert energy stored in glucose to ATP that can be used by cells
3 stages of respiration
- glycolysis
- citric acid cycle
- electron transport chain
glycolysis occurs in
cytoplasm
citric acid cycle occurs in
matrix of mitochondria
et chain occurs in
cristae
Main roles of ATP
- transfer of energy
2. phosphorylation of molecules
Phosphorylation=
addition of pi to a molecule like ADP that leads to more gain of ATP
What can fats and proteins be converted into?
intermediates of citric acid cycle and glycolysis
What are other sugars converted to?
glucose or intermediates of glycolysis
What breaks down into glucose?
start and glycogen
What can metabolic rate be measured as?
- oxygen consumption per unit time (respirometer)
- carbon dioxide consumption per unit time
- energy production (as heat) per unit time (calorimeter)
High metabolic rates require
efficient delivery of oxygen to cells
Best measure of fitness in humans=
maximum oxygen uptake
Incomplete double circulatory system
2 entries for blood, deoxygenated from body and oxygenated from lungs, mixing of blood- amphibians
Single circulatory system
blood flows in a single circuit, blood reoxygenated at the gills- fish
Double complete circulatory system
Closed loops for oxygenated and deoxygenated blood, efficient delivery of oxygen to cells- birds and mammals
Amphibian lungs
- gas exchange happens through mucosa in mouth and through the skin
- small lungs with alveoli can be used during rigorous activity
Reptile and mammal lungs
- branching tubes that end with alveoli, moist inner lining
- bidirectional airflow and gas exchange over large surface area