Metabolism Flashcards
The body requires?
A constant supply of Glucose
Type 1 Diabetes
Autoimmune dysfunction involving the destruction of beta cells
- Heredity
- No insulin at all
Type 2 Diabetes
Progressive condition due to increasing inability of cells to respond to insulin and decreased production of insulin
- Obesity, sedentary lifestyle, heredity
- Metabolic Syndrome
- Insulin resistant
Diagnosing Diabetes
- HgbA1C over 6.5%
AND
Symptoms of diabetes + random serum glucose over 200
OR
Fasting serum glucose over 126 mg/dl
OR
2h serum glucose over 200 in oral glucose tolerance test
Hyperglycemia Symptoms
- Polyuria, polydipsia, polyphagia
- Kussmauls Respirations - remove ketones
- Hypovolemia
- Recurrent infections and non healing wounds
- Skin changes
DKA
- RAPID onset
- Glucose over 300
- Ketones in urine and blood
Acanthosis Nigricans
Type 2 Diabetes Sign
- Skin, neck fold
DKA Treatment
- Monitor glucose levels
- Fluid and electrolyte management
- Insulin therapy
- Acidosis management
-Hyperkalemia than hypo
HHS
- SLOW onset
- Glucose over 600
- Ketones absent
- No acidosis
HHS Treatment
- Fluids!!!
- Insulin therapy
- Monitor electrolytes
- Hyper and hypo kalemia
Complications of Hypoglycemia
Causes: Insulin excess vs deficient food
Manifestations: Anxiety, sweating, hypoglycemia, unawareness, coma, seizures possible
Treatment: 15 g rapid acting card, dextrose ( 25-50% IV ) or Glucagon SQ, IM
Interventions for Diabetes
- Limit trans fat, 25 g of fiber, avoid sugars
- CHO counting, 1 unit of rapid acting insulin per 15 g CHO
- 150 min of exercise
- Weight loss ( 10% )
Osteoporosis Modifiable Risk Factors
- Low bodyweight
- Poor nutrition
- Caffeine intake
- Chronic low Cal, Vit D
- High ETOH intake
- Smoker
- Low estrogen
- Sedentary lifestyle
Osteoporosis Non-Modifiable Risk Factors
- Family history
- Age ( Over 50 )
- Female
- Menopause
- Anorexia
- Kidney/ Liver Disease
Osteoporosis Assessment
- Reduction height of 5 to 7.5 cm ( 2-3 inch )
- Kyphosis
- Acute / chronic back pain
- Restriction in movement
- History of fractures
What electrolytes are involved in the development of osteoporosis?
- Calcium and phosphorous
Labs and Diagnostics for Osteoporosis
- Blood calcium , Vit D, phosphorous, ESR, alkaline phosphate
- 24 hr urine
- Bone turnover
- Xray
- DEXA Scan
- CT/MRI
Osteoporosis Med Considerations
- Calcium supplementation
- **Raloxifene hydrochloride ( hormonal agent )
- Bisphosphonates
- Alendronate and Risedronate
- Estrogen replacement ( ERT )
- Premarin
Osteoporosis Complications
- Fractures: Lead to increased risk of death within 1 year following
- Weakening of the bones; stress fractures
- Caused by coughing, bending over
Hyperthyroidism
Caused by excessive thyroid hormone
Risk factors: Graves, thyroiditis, toxic adenoma