Metabolism

Question 1

P1

Answer 1

Hydrolysis
Oxidation
Reduction

Question 2

Billiary excretion

Answer 2

sulfate or glucuronide

high drug MW

Question 3

Beta gluuronidases and sulfatases can

Answer 3

regenerate drug.

Question 4

Most important enzyme in drug metabolism

Answer 4

CYP3A4/5

Question 5

CYP1,2,3

Answer 5

Xenobiotics , arachidonic acid , eicosanoids

Question 6

Most abundant in the liver

Answer 6

CYP3A4/5

Question 7

Things done by CYP450

Answer 7

aromatic hydroxylation

aliphatic hydroxylation

N,O,S -dealkylation

Question 8

Highly polymorphic enzymes

Answer 8

CYP2C9
CYP2C19
CYP2D6

Question 9

Major P2 reactions

Answer 9

Glucuronidation

Sulfation

Glutathione conjugation

Question 10

Very important in steroids

Answer 10

Sulfation

Question 11

Hydroxylation of phenobarbital will

Answer 11

inactivate

Question 12

S-oxidation of chlorpromazine

Answer 12

inactivates

Question 13

All epoxides are

Answer 13

reactive electrophiles

Question 14

Electrophiles will binds to

Answer 14

DNA , RNA , Protein …

Can be marked by albumin

Question 15

95% from GI tract ,goes to the liver and it will be metabolized in the liver.. determines what enters circulation and bioavailability.

Answer 15

If very large 4500 daltons, they will be excreted into bile and dumped into intestines. Can lead to enterohepatic circulation and be reabsorbed.

Question 16

P450s

Answer 16

major major with Phase 1