Metabolic processes Flashcards
What is cellular respiration?
a series of chemical reactions that break down glucose to produce ATP
What is glycolysis?
10 enzyme-catalyzed reactions which changes 6-carbon glucose into two 3-carbon pyruvates and creates ATP and GDP
What is the first step of glycolysis?
glucose receives phosphate group from ATP and produces glucose-6-phosphate
What is the second step of glycolysis?
glucose-6-phosphate is rearranged into fructose-6-phosphate
What is the third step of glycolysis?
another phosphate group is added from ATP to fructose-6-phosphate to create fructose-1,6-bisphosphate
What is the fourth step of glycolysis?
fructose-6,1-bisphosphate is split into glyceraldehyde-3-phosphate (G3P) and dehydroxyacetone phosphate (DHAP)
What is step five of glycolysis?
DHAP from rxn four is converted into G3P, everything after this happens twice
What is step six of glycolysis?
G3P is oxidized, those electrons are accepted by NAD+ to form NADH, forms 1,3-bisphosphate
What is step seven of glycolysis?
phosphoglycerate group in 1,3-bisphosphoglycerate is transferred to ADP to produce ATP, left with 3-phosphoglycerate
What is step eight of glycolysis?
3-phosphoglycerate rearranges to 2-phosphoglycerate
What is step nine of glycolysis?
H2O is removed from 2-phosphoglycerate and electrons are moved within the molecule, forms phosphoenolpyruvate (PEP)
What is step ten of glycolysis?
remaining phosphate group is removed from PEP and transferred to ADP, forms ATP and pyruvate
What are all the products/reactants of glycolysis?
Glucose, glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-bisphosphate, DHAP, G3P, 1,3-bisphosphate, 3-phosphoglycerate, 2-phosphoglycerate, phosphoenolpyruvate, pyruvate
What are all the steps in cellular respiration?
glycolysis, pyruvate oxidation, Krebs cycle, electron transport chain, chemiosmosis, oxidative phosphorylation
What is pyruvate oxidation?
pyruvate enters the mitochondrial matrix, pyruvate is oxidized, NAD+ is reduced, CoA is added, forms NADH + H+, CO2, and Acetyl CoA
What is the Krebs cycle?
series of reactions to release the energy stored in nutrients (form ATP)
What is the first step in the Krebs cycle?
Acetyl CoA joins with oxaloacetate, CoA leaves, forms citrate
What is the second step of the Krebs cycle?
citrate isomerizes into isocitrate with the addition and removal of water
What is the third step of the Krebs cycle?
isocitrate decarboxylizes to form alpha ketoglutarate, NAD+ is converted to NADH
What is the fourth step of the Krebs cycle?
alpha ketogluterate decarboxylizes, CoA is added, NAD+ is converted to NADH, forms succinyl CoA
What is the fifth step of the Krebs cycle?
GDP loses a phosphate, becomes GTP, GTP phosphate is transferred to ADP to form ATP, CoA leaves, forms succinate
What is the sixth step of the Krebs cycle?
succinate oxidizes into fumarate, FAD becomes FADH2
What is the seventh step of the Krebs cycle?
fumarate becomes malate by the addition of H2O
What is the eighth step of the Krebs cycle?
malate becomes oxaloacetate, NAD+ becomes NADH