Metabolic Medicine

Question 1

What HLA antigens are associated with T1DM?

Answer 1

HLA-B8
HLA-BW15
HLA-DR3
HLA-DR4

Question 2

What genetic factor increases risk of developing T1DM to greatest degree?

Answer 2

Absence of aspartic acid in HLA-DQB chain (homozyogsity)

confers 100-fold increased risk

Question 3

What are the peak incidences of T1DM presenting?

Answer 3

5-7yrs (when children start school and exposure to viral infection increases)

and

At puberty (10-14 years)