Metabolic Bone Dz: Gosmanov

Question 1

A T Score of -2.5 with no hx of low trauma resulting in fracture is indicative of:

Answer 1

Osteoporosis. This justifies tx

Question 2

A T Score of greater than -2.5 with a low trauma fracture history is indicative of:

Answer 2

Osteoporosis. This justifies tx

Question 3

Describe the biochemical markers of bone turnover.

Answer 3

Bone formation:
::None-specific alkaline phosphatase
::Osteocalcin
::Carboxyterminal propeptide of type 1 collagen (P1NP)

Bone resorption:
::N-telopeptide
::Carboxyterminal of type 1 collagen (CTX-1)

Question 4

Describe the tx of idiopathic osteoporosis as far as 1) optimizing life style and 2) pharmacological tx

Answer 4

1) 
Stop tobacco/EtOH use.
Incr. physical activity
Adequate Ca in diet (1200mg/day)
Optimize Vit. D level (>30ng/mL)
Fall prevention

2)
Antiresorptive agents
Anabolic agents

Question 5

Isolated rise in serum alk phos is indicative of this disease:

Answer 5

Paget’s Dz of bone

Question 6

Pts of most metabolic bone diseases experience bony pain except for patients of this condition:

Answer 6

Osteoporosis