Metabolic Flashcards
1
Q
Causes of SIADH
A
Major surgery
ADH secretion
- bronchogenic carcinoma
- adenocarcinoma
- lymphoma
Drugs
- antidepressants: SSRI, TCA
- antipsychotics: haloperidol
- chemo
- amiodarone, ciprofloxacin
CNS disorders
Hormone deficiency
- adrenal insufficiency
- hypothyroidism
Others
- GBS
- HIV (pjp)
Pulmonary disorders
- pneumonia
- TB
- lung abscess
2
Q
Diagnosis of SIADH
A
Urinary Na > serum Na Urinary Na > 20mmol Euvolaemia Normal TFTs and adrenal function No diuretic use Normal cardiac, hepatic, renal function
3
Q
Causes of hyponatraemia
A
Hypovolaemia
- excessive loss
- urinary Na < 20mmol extrarenal loss due to sweating, vomiting, diarrhoea, pancreatitis
- urinary Na > 20mmol renal loss thiazides, osmotic diuresis, RTA or CKD
Euvolaemia
- SIADH (diagnosis of exclusion)
- beer potomania
- psychogenic polydipsia
- drugs
- H2O intoxication
Hypervolaemia
- failures
- urinary Na > 20mmol renal failure
- urinary Na < 20mmol cirrhosis, cardiac failure, nephrotic syndrome
