Metabolic 3 Flashcards
1
Q
Outline the hypermetabolic responses to injury
A
- Increased blood pressure & heart rate
- Peripheral insulin resistance
- Increased protein and lipid catabolism
- Increased resting energy expenditure
- Increased body temperature
- Total body protein loss
- Muscle wasting
- Acute-phase protein response
2
Q
What are the endocrine complications that occur during starvation? (adrenal)
A
- Increased HPA activity
- Stress of chronic starvation
High cortisol (glucocortcoid)
Breakdown of protein (muscle, collagen) to glucose & urea
Loss of collagen: Osteopenia
Loss of muscle: Weakness
3
Q
What are the endocrine complications that occur during starvation? (thyroid)
A
Sick euthyroid pattern:
TSH low-normal, FT4 low-normal, FT3 low
Due to chronic undernutrition
- Decreased metabolic rate
Decreased conversion FT4 to FT3 (low)
TSH & FT4 levels: low normal or low
Reduced metabolic rate
