Messias TBL 2 Flashcards
1st gen AP’s described as messy were known to be anti muscarinic causing:
Anticholinergic (dry mouth, blurry vis., constip.), histamine blockade, sedation, and weight gain
Which AP is associated with agranulocytosis?
Clozapine
Which drug is the only AP with proven efficacy for REFRACTORY schizophrenia?
Clozapine
Decreased dopamine in what area of the brain is thought to produce the negative effects associated with schizophrenia?
Frontal Cortex
Tuberoinfundibular pathway inhibits what hormones release?
Prolactin
In schizophrenia how does the mesocortical pathway contribute?
Hypo activity for negative symptoms
How does the mesolimbic pathway affect schizophrenia?
Hyperactivity leading to positive symptoms
Which AP is most associated with “extrapyramidal sides” and EPS eliciting sides?
Haloperidol
What are the common sides from 1st gen chlorpromazine?
Less eps, more sedation, hypotension, dry mouth, delirium.
What is the recommended dose of respiridol? What enzyme breaks it down?
2-6 mg
2D6 isoenzyme
What’s the therapeutic range for olanzapine? What breaks it down? What makes it metabolized faster?
10-20 mg
CYP1A2 (smoking)
What’s the doc of patients with Parkinson’s that have associated psychotic symptoms from L-Dopa tx.?
Quetipine
What two AP’s are known as “fast off” drugs?
Clozapine and quetipine
Which AP is described as a partial agonist?
Apripriza
Which AP can cause nausea from activating the CYZ?
Aripiprazole