Messias TBL 2 Flashcards

1
Q

1st gen AP’s described as messy were known to be anti muscarinic causing:

A

Anticholinergic (dry mouth, blurry vis., constip.), histamine blockade, sedation, and weight gain

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2
Q

Which AP is associated with agranulocytosis?

A

Clozapine

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3
Q

Which drug is the only AP with proven efficacy for REFRACTORY schizophrenia?

A

Clozapine

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4
Q

Decreased dopamine in what area of the brain is thought to produce the negative effects associated with schizophrenia?

A

Frontal Cortex

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5
Q

Tuberoinfundibular pathway inhibits what hormones release?

A

Prolactin

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6
Q

In schizophrenia how does the mesocortical pathway contribute?

A

Hypo activity for negative symptoms

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7
Q

How does the mesolimbic pathway affect schizophrenia?

A

Hyperactivity leading to positive symptoms

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8
Q

Which AP is most associated with “extrapyramidal sides” and EPS eliciting sides?

A

Haloperidol

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9
Q

What are the common sides from 1st gen chlorpromazine?

A

Less eps, more sedation, hypotension, dry mouth, delirium.

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10
Q

What is the recommended dose of respiridol? What enzyme breaks it down?

A

2-6 mg

2D6 isoenzyme

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11
Q

What’s the therapeutic range for olanzapine? What breaks it down? What makes it metabolized faster?

A

10-20 mg

CYP1A2 (smoking)

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12
Q

What’s the doc of patients with Parkinson’s that have associated psychotic symptoms from L-Dopa tx.?

A

Quetipine

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13
Q

What two AP’s are known as “fast off” drugs?

A

Clozapine and quetipine

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14
Q

Which AP is described as a partial agonist?

A

Apripriza

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15
Q

Which AP can cause nausea from activating the CYZ?

A

Aripiprazole

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16
Q

What’s the treatment of an ADS?

A

Intramuscular benztropine (cogent in) or diphenhydramine (Benadryl)

17
Q

What type of EPS is typically first to appear?

A

Acute dystonic reactions

18
Q

What is akathisia?

A

Inability to sit

19
Q

What’s the treatment for akathisia?

A

Propanol

20
Q

Which two drugs are at higher risk for akathisia?

A

Haloperidol and ariprazole

21
Q

What are the typical txs. for parkinsism?

A

Benztropine and trigexyphenidyl.

Amantadine

22
Q

In the short term with TD what are the efx. With 1) lowering the dose 2) raising the dose of AP

A

Lowering increases TD and vice versa

23
Q

What is the typical treatment for nms?

A

Immediate admittance to ICU with iv hydration

24
Q

What drug is used to reverse prolactemia?

A

Apriprazole

25
Q

Which drugs are associated with hyperprilactinemia

A

Haloperidol

Risoeridone and palioeridone

26
Q

Because of its strong affect on triglycerides which AP is a higher risk for coronary artery disease?

A

Quietepine

27
Q

What two drugs are at higher risk for weight gain and which two are lowest?

A
  • clozapine and olanzapine

- Apriprazole and ziprasidone

28
Q

Name some lai’s:

A

TWO NAMES!!!!:

Haloperidol deconate, risperidone microspheres, olanzapine pamoate