Brains 3

Question 0

Irritation of the lateral olfactory area producing olafactory hallucinations such as burning rubber and involuntary tongue and lip movement is known as:

Answer 0

Uncinate Fits

Question 1

Fractures to the floor of anterior cranial fossa allowing leakage of CSF is known as?

Answer 1

Rhinorrhea

Question 2

Tumor arising from the floor of the anterior cranial fossa that impinges on olafactory bulbs is known as a:

Answer 2

Meningioma

Question 3

Which portion of the hypothalamus regulates hunger/feeding?

Answer 3

Lateral Hypothalamus

Question 4

Electrical stimulation to what area produces intense pleasure?

Answer 4

Septal Area

Question 5

Lesions to what area produces Kluver Bucy Syndrome?

Answer 5

Bilateral lesions to the temporal lobe

Question 6

What condition produces loss of fear, rage, and aggression? While also showing hyper sexuality, psychic blindness, and overly attentive to sensory stimuli.

Answer 6

Kluver Bucy Syndrome

Question 7

Electrical stimulation to what area produces olafactory hallucinations?

Answer 7

Entorhinal Cortex

Question 8

Functions of hippocampus? Products of lesions?

Answer 8

1) allows short term memory to be converted long term memory

2) LARGE lesions produce short term memory loss with no effect on long term

Question 9

What two nucleuses control fluid balance and blood pressure regulation? Specifically adh and oxytocin. What happens in the event of the destruction of these two nucleuses?

Answer 9

Supraoptic and Paraventricular nucs. Diabetes Insipidus

Question 10

How does the posterior pituitary gland communicate with the hypothalamus?

Answer 10

Hypothalamo-hypophyseal tract

Question 11

How does the anterior pituitary gland communicate with the hypothalamus?

Answer 11

Hypophyseal Portal System

Question 12

What’s the blood supply to the hypothalamus?

Answer 12

Perf. Branches of the Circle of Willis

Question 13

Where do the anterior pituitary hormones get released into the blood?

Answer 13

Via the hypophyseal portal system into the cavernous sinuses

Question 14

Function of the mu subtype of opoid:

Answer 14

SUPRASPINAL

Question 15

What drug is a competive antagonist for the Benzo binding site, thus blocking activity of Benzo’s and Z drugs?

Answer 15

FLUMAZENIL

Question 16

What does the major adult isoform of the GABA-A receptor consist of?

Answer 16

2 alpha, 2 beta, 2 y subunits

Question 17

Where does GABA bind to on the GABA-A receptor?

Answer 17

Between the 2 alpha and 2 beta units

Question 18

If there are suspected liver problems with the patient which BENZO’s should be prescribed?

Answer 18

LOT/ On The Liver (No active metabolites)
Lorazepem
Oxazepam
Temazepam

Question 19

Binding site and action of BENZO?

Answer 19

Binds between the alpha 1 and y 2 subunit

INCREASES FREQUENCY OF CL- channel opening (MAKING BEN HAPPY ;) )

Question 20

Binding site of Z-Drugs?

Answer 20

Binds to BENZO receptor BZ-1 (omega-1)

Question 21

Action of BARB?

Answer 21

Increases DURATION of Cl- Channels (Making BARB HAPPY ;)

Question 22

Describe the half life and potential withdrawal problems with Flumazenil?

Answer 22

SHORT HALF LIFE (30-60 minutes)

-Can cause precipatated withdrawal in benzo dependant patients, including seizures and respiratory depression.

Question 23

MOA of buspirone?

Answer 23

5 HT1a partial agonist

Question 24

What is the only approved use for Buspirone?

Answer 24

General Anxiety D/O - 2nd line of tx. after SSRI/SNRI - SLOW ONSET (2-6 weeks)

Question 25

MOA of ramelton?

Answer 25

Agonist at MT1 and MT2 Melatonin Receps. - M1 (Sleep Onset) - M2 (Circadium Rhythms) - Increased sleep time, decreased sleep latency

Question 26

What specific medical D/O's should you be aware of when prescribing BARBS?

Answer 26

ACUTE INTERMITTENT PORPHYRIA and PORPHYRIA VARIEGATA - Because they enhance porphyria synthesis - ALSO THEY INDUCE CYP450 so D-D interaxns should be considered!

Question 27

In the different MOA's of thalamus neurons describe the actions and functions of both 1) Tonic and 2) Burst firing?

Answer 27

A) -55 mV, Ca++ NOT active, Detailed Info/Focusing | B) Burst of Ca++ (ACTIVE), -70 mV, No details, also active in sleep (aware of event)

Question 28

What is the affect of a Non-Pinealocyte tumor?

Answer 28

Decreased Melatonin=Precocious Puberty! (HYPER GONADISM)

Question 29

What is the affect of a Pinealocyte tumor?

Answer 29

Increased MELATONIN (hyper active pineal gland=HYPOGONADISM)

Question 30

To which receptor does endorphins have the most affinity for?

Answer 30

Mu, receptors

Question 31

To which receptor does Enkephalics have the most affinity for?

Answer 31

Delta receptors

Question 32

To which receptor does dynorphins have the most affinity for?

Answer 32

Kappa Receptors