Mental Health: depression Flashcards

1
Q

Prevalence of depression

A
  • 8 - 12% of UK population experience depression in any year
  • more common in women in most age groups
  • common in patients with physical illness
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2
Q

Aetiology of depression

A
  • Multifactorial
  • Biochemical
  • Neuroendocrine
  • Genetic
  • Social
  • Psychodynamic

Biopsychosocial model:
•Biological

  • Psychological
  • Social
  • Predisposing
  • Precipitating
  • Perpetuating
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3
Q

Screening for depression

A

The following two questions can be used to screen for depression

  • ‘During the last month, have you often been bothered by feeling down, depressed or hopeless?’
  • ‘During the last month, have you often been bothered by having little interest or pleasure in doing things?’

A ‘yes’ answer to either of the above should prompt a more in depth assessment.

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4
Q

Diagnostic criteria for a depressive episode

A
  • Depression can be mild, moderate or severe
  • Diagnostic guidelines are that symptoms should last for at least 2 weeks, there are no symptoms (current or historic) that could indicate bipolar affective disorder and there are no other possible causes (organic / substance misuse)
  • At least 2 of the 3 core symptoms must be met, most days for most of the time:
  • Low mood
  • Loss of interest or pleasure in activities usually interesting or pleasurable (anhedonia)
  • Decreased energy levels (anergia)
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5
Q

What are core symptoms of depression?

A
  • Low mood
  • Loss of interest or pleasure in activities usually interesting or pleasurable (anhedonia)
  • Decreased energy levels (anergia)
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6
Q

number of other symptoms needed to assess the level of depression

A

Number of core + additional symptoms → determine the level of depression (2 core needed to diagnose depression)

  • 2 core + 2 additional symptoms = mild depression
  • 2 core and 4 additional symptoms = moderate depression
  • 3 core and at least 5 additional symptoms = severe depression
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7
Q

Other (apart from core) symptoms of depression (apart from core symptoms they are needed to describe the severity of depression)

A
  • Loss of confidence / self esteem
  • Guilt - feelings of self reproach
  • Recurrent thoughts of death, recurrent suicidal ideation
  • Diminished ability to think or concentrate, or indecisiveness
  • Change in psychomotor activity (agitation or retardation)
  • Sleep disturbances (of any type)
  • Appetite disturbance, either decreased (anorexia) or increased (leading to hyperphagia)
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8
Q

Symptoms characteristics required for the diagnosis of depression (3)

A
  • Symptoms should be present nearly every day
  • The symptoms cause clinically significant distress or impairment in social, occupational or other important areas of functioning
  • The symptoms are not due to the direct physiological effects of a substance (e.g. a drug of abuse, a medication) or a general medical condition (e.g. hypothyroidism)
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9
Q

Psychosis and depression

A
  • Severe depression may occur with or without psychotic symptoms
  • Usually, psychotic symptoms are “mood congruent”, i.e. nihilistic delusions, persecutory hallucinations etc.
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10
Q

Physical symptoms of depression

A
  • Loss of libido
  • Physical complaints (i.e. somatic symptoms), e.g. aches, pains, constipation, increased worry about pre-existing medical problems
  • Diurnal variation of mood (worst in the morning, improves as the day progresses)
  • Irritability
  • Anxiety, worry, dread, catastrophising
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11
Q

Thoughts pattern in depression

A
  • Negative about self, world and future
  • Helpless, worthless
  • Worthless, useless, inadequate
  • Burden, others better off without them
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12
Q

What does the severity of the depressive episode depend on?

A
  • Number of symptoms of depression
  • Degree of functional impairment
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13
Q

Diagnosis and management of mild depression

A
  • enough symptoms to meet criteria
  • a person with a mild depressive episode is probably capable of continuing with the majority of their activities
  • Managed in primary care → Non-pharmacological treatment only
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14
Q

Moderate depressive episode

  • characteristics
  • management
A
  • Between mild and severe
  • A person with a moderate depressive episode will probably have difficulties continuing with their ordinary activities

Management:

  • May require secondary care
  • Combination of treatment (i.e. medication and psychological therapy)
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15
Q

Severe depression

  • characteristics
  • management
A
  • People with this type of depression have symptoms that are marked and distressing
  • Suicidal thoughts and acts are common
  • Psychotic symptoms may be present, e.g. hallucinations, delusions, psychomotor retardation or severe stupor (referred to as a severe depressive episode with psychotic symptoms)

Management:

  • usually require secondary services
  • may require treatment in hospital
  • may require detention under Mental Health Act 1983
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16
Q

(3) categories of management of depression

A
  • Biological
  • Psychological
  • Social
17
Q

Biological management of depression

A

Antidepressant medication:

  • SSRI
  • Dual re-uptake inhibitors (SNRI)
  • Tricyclics
  • MAO inhibitors
  • Others
18
Q

What we may need to add to antidepressants?

A
  • Antipsychotics (Quetiapine, Risperidone, Aripiprazole)
  • Lithium Carbonate
  • Addition of a second antidepressant (either SSRI + Mirtazapine or Mirtazapine + Venlafaxine)
19
Q

How long does treatment with anti-depressants last?

A
  • a single episode of depression should be treated for at least 6 to 9 months after remission
  • the risk of recurrence is high and increases with each episode
  • multiple episodes may require treatment for years
  • the chances of staying well are greatly increased by taking antidepressants
20
Q

Advantages of anti-depressants

A
  • Effective
  • Not addictive
  • Not known to loose their efficacy over time
  • Not known to cause new long-term side effects
  • Need to be continued at treatment dose
21
Q

Stopping anti-depressants

A
  • Must not be stopped abruptly
  • May lead to unpleasant discontinuation effects
  • Confers higher risk of relapse
  • Antidepressants should be reduced slowly and under supervision of a doctor
  • May have discontinuation effects however slowly reduced
22
Q

Indications for electroconvulsive therapy (ECT)

A
  • only to achieve rapid and short-term improvement of severe symptoms after an adequate trial of other treatment options has proven ineffective and / or when the condition is considered to be potentially life-threatening, in individuals with:
  • severe depressive illness
  • catatonia
23
Q

Side effects of ECT

A

Short-term side-effects

  • headache
  • nausea
  • short term memory impairment
  • memory loss of events prior to ECT
  • cardiac arrhythmia

Long-term side-effects

  • some patients report impaired memory
24
Q

Contraindications for ECT

A

The only absolute contraindications is raised intracranial pressure

25
Q

Psychological treatments for depression

A
  • Counselling
  • Cognitive Behavioural Therapy (CBT)
  • Mindfulness
  • Interpersonal Therapy (IPT)
  • Groups, such as self-help, self-esteem, self-confidence
  • Anxiety management
  • Relaxation techniques
26
Q

Social treatments for depression

A
  • Exercise
  • Signposting
  • Housing
  • Finances
  • Social Services
27
Q
  • First-line pharmacological treatment for depression
  • name preferred drugs (2)
  • what drug to use if post-MI?
A

Selective serotonin reuptake inhibitors (SSRIs)

  • citalopram (careful in QT interval) and fluoxetine are currently the preferred SSRIs
  • sertraline is useful post myocardial infarction as there is more evidence for its safe use in this situation than other antidepressants
28
Q

What antidepressant to use in children and adolescent?

A

SSRIs should be used with caution in children and adolescents

Fluoxetine is the drug of choice when an antidepressant is indicated

29
Q

SEs of SSRIs

A
  • Gl symptoms
  • there is an increased risk of GI bleeding in patients taking SSRIs. A proton pump inhibitor should be prescribed if a patient is also taking a NSAID
  • patients should be counselled to be vigilant for increased anxiety and agitation after starting a SSRI
  • fluoxetine and paroxetine have a higher propensity for drug interactions
30
Q

Citalopram and QT interval

A
  • citalopram and escitalopram are associated with dose-dependent QT interval prolongation and should not be used in those with: congenital long QT syndrome; known pre-existing QT interval prolongation; or in combination with other medicines that prolong the QT interval
  • the maximum daily dose is 40 mg for adults; 20 mg for patients older than 65 years; and 20 mg for those with hepatic impairment
31
Q

SSRIs interactions with other drugs

A
  • NSAIDs: ‘do not normally offer SSRIs’, but if given co-prescribe a proton pump inhibitor
  • warfarin / heparin: recommendation to avoid SSRIs and considering mirtazapine
  • aspirin: see above
  • triptans - increased risk of serotonin syndrome
  • monoamine oxidase inhibitors (MAOIs) - increased risk of serotonin syndrome
32
Q

When to review a patient after starting SSRI?

A
  • Following the initiation of antidepressant therapy patients should normally be reviewed by a doctor after 2 weeks
  • For patients under the age of 30 years or at increased risk of suicide they should be reviewed after 1 week
  • If a patient makes a good response to antidepressant therapy they should continue on treatment for at least 6 months after remission as this reduces the risk of relapse
33
Q

Symptoms of SSRIs discontinuation

A

When stopping a SSRI the dose should be gradually reduced over a 4 week period (this is not necessary with fluoxetine). Paroxetine has a higher incidence of discontinuation symptoms.

Discontinuation symptoms:

  • increased mood change
  • restlessness
  • difficulty sleeping
  • unsteadiness
  • sweating
  • gastrointestinal symptoms: pain, cramping, diarrhoea, vomiting
  • paraesthesia
34
Q

SSRIs and pregnancy

A
  • to weigh up benefits and risk when deciding whether to use in pregnancy
  • use during the first trimester gives a small increased risk of congenital heart defects
  • use during the third trimester can result in persistent pulmonary hypertension of the newborn

*Paroxetine has an increased risk of congenital malformations, particularly in the first trimester