menopause Flashcards

1
Q

when do you begin screening women for osteoporosis

A

healthy women by age 65

earlier if women smoke, drink, RA, hx of fractures, dz/meds that add to the risk, body weight less than 127

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2
Q

combo estrogen and progestin Hormone Therapy

increases risk of

but decreases risk of

A

increases risk of:

  • thromboembolic events
  • breast CA
  • CVD
  • stroke

decreases risk of

  • fractures
  • colon CA
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3
Q

what are some non-pharmacologic osteoporosis preventative measures that pts can take

A

exercise: weight bearing, resistance, walking, aerobics

nutrition:

increase Ca to 1200 mg/ day at age 50

increase Vit D to 800 at age 70

avoid:

smoking, ETOH

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4
Q

laboratory diagnosis of perimenopause

A

FSH > 25

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5
Q

what are the non-hormonal pharmacological treatments for the vasomotor sxs of perimenopause and menopause

A

SSRIs (esp. LD paroxetine)

SNRIs

centrally acting anti-epileptics (gabapentin, pregabalin, clonidine)

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6
Q

vaginal vault apical pelvic prolapse

A

enterocele

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7
Q

stage 1 pelvic organ prolapse

A

more than 1 cm from the hymenal ring (inside)

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8
Q

Hispanic women are more susceptible to ___

A

pelvic organ prolapse

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9
Q

stage 3 pelvic organ prolapse

A

beyond 1 cm past the hymenal ring but still in vagina

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10
Q

what type of hormone therapy do you give

to a woman who has

undergone a hysterectomy

A

estrogen only

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11
Q

posterior compartment pelvic prolapse

A

rectocele

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12
Q

why is progestin added to estrogen in Hormone Therapy for women with a uterus

A

to decrease the risk of endometrial hyperplasia and endometrial CA

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13
Q

what type of hormone therapy do you give

to a woman who

still has an intact uterus

A

combo estrogen and progestin

(b/c unopposed estrogen with a uterus can cause endometrial hyperplasia and increase the risk of endometrial CA)

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14
Q

what are the components of the genitourinary syndrome of menopause

A

vulvovaginal atrophy (dryness, itching, dyspareunia)

sexual dysfunction

urinary frequency

recurrent bladder infections

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15
Q

white women and menopausal side effects

more susceptible to ___

A

osteoporosis

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16
Q

DEXA T score’s:

normal

osteopenia

osteoporosis

A

normal = - 1 +

osteopenia = - 1 to - 2.5

osteoporosis = less than - 2.5

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17
Q

when treating a patient w/ systemic hormone therapy,

what should the dose be?

for how long should they take it?

A

lowest effective dose

for the shorterst duration needed

(generally not more than 5 years or beyond 60)

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18
Q

how do you treat the sexual dysfunction sxs of postmenopause

why would not give everyone this (side effects)?

A

testosterone

but

side effects: lipids, clitoromegaly, hirsutism, and acne

19
Q

risk factors for pelvic organ prolapse

A
  • vaginal deliveries
  • advanced age/ menopause
  • obesity
  • CT disorder
  • chronic dz (constipation/ COPD)
  • Hispanic
20
Q

stage 4 pelvic organ prolapse

A

beyond the vagina

21
Q

asian women and menopausal side effects

more susceptible to ___

less susceptible to ___

A

more susceptible to osteoporosis

less susceptible to vasomotor sxs

22
Q

how often do you monitor osteoporosis once you begin?

A
  • normal BMD- Q 5 to 15 years
  • osteopenia (-1.5 to -1.99)- Q 5 years
  • osteopenia (-2 to -2.5)- yearly
  • osteoporosis- after tx Q2 years
23
Q

pelvic organ prolapse treatment

A

pessary

pelvic floor muscle exercises (kegels)

surgical tx (symptomatic/ refractory)

24
Q

what are the non-pharmacological treatments for the vasomotor sxs of perimenopause and menopause

A

lifestyle mods (layering clothes, avoid ETOH and caffeine)

exercise

phytoestrogens (soy, red clover)

herbal remedies (black cohosh, ginseng, ginkgo

vitamin E

accupuncture

** limited data for all of this **

25
Q

how do you pharmacologically treat the vasomotor sxs of menopause (and perimenopause)

A

Hormone Therapy

SSRIs and SNRIs

clonidine

gabapentin

26
Q

pelvic prolapse where the uterus/ vaginal vault protrudes out of vagina

A

procidentia

27
Q

disadvantages of pessaries

A

odor

discharge

vag ulcers

erosion into bladder

fistula formation

ureteral obstruction w/ urosepsis or uremia

small bowel prolapse and incarceration

28
Q

stage 2 pelvic organ prolapse

A

from 1 cm before the hymenal ring to 1 cm beyond the hymenal ring

29
Q

heaviness/ pressure/ pain/ irritation/ discomfort

urinary incontinence/ retention

defecation sxs

feels like something is bulging outside of vagina

A

pelvic organ prolapse

30
Q

what are the 3 types of pelvic organ prolapse surgeries

A

fixation to the sacrospinous ligament

fixation to the uterosacral ligament

sacrocolpopexy (fixation to the anterior longitudinal ligament)

31
Q

how do you determine risk for osteoporosis related fracture

A

FRAX score

10 year risk assessment

32
Q

when do you enter menopause

A

after 12 months without menstruation, avg age 51.5, younger than 40 is abnormal

33
Q

osteoporosis diagnosis

A

DEXA (use T score to diagnose osteoporosis in post-menopausal women)

or

having fragility fractures (fractures that occur from a fall of standing height or less)

34
Q

laboratory diagnosis of postmenopause

A

FSH > 70

35
Q

what are the routes of systemic Hormone Therapy

A

oral

transdermal- patch/ gel/ spray

36
Q

who gets osteoporosis tx

A

T score less than - 2.5

osteopenia + high risk

postmenopausal + hx of hip/ vertebral fracture

37
Q

black women and menopausal side effects

more susceptible to ___

less susceptible to ___

A

more susceptible to vasomotor sxs (hot flashes)

less risk of osteoporosis and pelvic organ prolapse

38
Q

estrogen only Hormone Therapy increases risk of

A

thromboembolic events

transdermal > oral

39
Q

osteoporosis pharmacologic tx

A
  • bisphosphonates- first line
    • dronates
  • Selective Estrogen Receptor Modulators- also reduces risk of breast CA
    • raloxifene
  • Recombinant PTH- severe
    • teriparatide
  • Calcitonin- short term acute pain relief
40
Q

vulvovaginal atrophy treatment

A

water soluble moisturizers and lube

estrogen (topical > oral)

estrogen agonists and antagonists that selectively stimulate and inhibit different targe tissues (ospemifene)

41
Q

how long does perimenopause last?

A

about 4 years til Final Menstrual Period (FMP)

42
Q

anterior compartment pelvic prolapse

A

cystocele

43
Q

contraindications for Hormone Therapy

A

breast CA

CVD

prior VTE/ stroke/ TIA

active liver dz

unexplained vag bleeding

high risk endometrial CA