Meningitis Flashcards

1
Q

Meningitis can be classified by etiology into:

A
  1. Bacterial meningitis
  2. Viral meningitis (aseptic)
  3. Fungal meningitis
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2
Q

Most common cause of meningitis is […]

A

Viral

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3
Q

What viral organism may cause meningitis ?

A

Enteroviruses (coxsackie)
HSV-2
HIV, West Nile, VZV

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4
Q

What bacterial organisms may cause meningitis ?

A
  • S. Pneumoniae
  • N. Meningitidis
  • H. Influenzae (non vaccinated)
  • GBS (neonates)
  • Listeria (extreme age, pregnant, immunocompromised)
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5
Q

What is the most common bacterial organism in meningitis ?

A

S. Pneumonea

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6
Q

Most common agent:
Meningitis in HIV patient

A

CD4 <50: Cryptococcus

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7
Q

Most common agent:
Meningitis with history of swimming in river

A

Naegleria fowleri

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8
Q

Most common agent:
Meningitis with petechial rash

A

Neisseria Meningitidis

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9
Q

What are the symptoms of meningitis

A

Fever
Headache
Photophobia
Nuchal regidity

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10
Q

Presentation of :

Fever
Headache
confused / altered sensation

A

Encephalitis

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11
Q

Presentation of :

Fever
Headache
focal neurological deficit

A

Brain abscess

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12
Q

What are the positive signs of meningitis on examination ?

A

Kernig’s (hip flexion)
Brudzinski’s (neck flexion)

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13
Q

Meningitis spread by […]

A

Droplet

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14
Q

Patient with meningitis need to be isolated for […] of antibiotics

A

24 hours

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15
Q

[…] is needed for diagnosis of meningitis

A

LP
with gram stain & culture

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16
Q

What are contraindications for LP in patient with meningitis ?

A

signs of 🔺ICP
- papilledema
- focal neurological deficit
- altered mental status
- new onset seizure
CNS lesion
immunocompromised

17
Q

What are the CSF findings in viral meningitis ?

A

Cell type :
Protein: N/🔺
Glucose: 🟢

18
Q

What are the CSF findings in bacterial meningitis ?

A

Cell type : PMNs
Protein: 🔺
Glucose: 🔻

19
Q

What are the CSF findings in fungal meningitis ?

A

Cell type :
Protein: 🔺
Glucose: 🔻

20
Q

What are the CSF findings in TB meningitis ?

A

Cell type :
Protein: 🔺🔺🔺
Glucose: 🔻

21
Q

Normal CSF cell count […]

22
Q

Meningitis with low attenuation over tempo-parietal area
Most common causative agent […]

23
Q

Most common late complication of meningitis […]

A

Hearing loss

24
Q

Viral Meningitis treatment

A

Supportive

25
Viral encephalitis treatment
Acyclovir (IV)
26
Bacterial meningitis empiric treatment
Vancomycin + Ceftriaxone + Dexamethasone + Ampicillin ( extreme age for Listeria )
27
What is the cephalosporin choice in meningitis in neonates
Cefotaxime
28
What is the cephalosporin choice in meningitis in immunocompromised / Neurosurgical patient
4th generation (cefepime /ceftazidime) Or meropenem to cover pseudomonas
29
What antibiotics used for meningitis caused by Listeria
Ampicillin (Alternative: TMP-SMX)
30
Prophylaxis to contacted people of meningitis :
**Ciprofloxacin** - pediatrics: 2 doses **Rifampicin** - pregnant: **Ceftriaxone**
31
Meningitis culture positive for MRSA The antibiotic of choice is :
Vancomycin
32
What is the role of dexamethasone in meningitis
Decrease mortality Prevent sequela from autoimmune reaction against lysed bacteria **(S. Pneumo)** (Deafness, Vision loss, focal neurological deficit) Give for 4 days if culture positive
33
**CSF analysis:** Bacterial Viral TB Cryptococcal SAH MS
Bacterial: 🔻Glc 🔺Nø Viral: 🟢Glc 🔺Lø <300 TB/fungal: 🔻Glc 🔺Lø <500 Cryptococcal: india ink SAH: xanthochromia (RBC) MS: oligoclonal bands