MEN Syndromes - Krafts

Question 1

What are MEN Syndromes?

Answer 1

Genetic disorders

MEN-1 and MEN-2

Predispose to endocrine tumors

Tumors are worse in MEN!

Question 2

How is MEN-1 different from MEN-2?

Answer 2

Thyroid: Not much

Other endocrine organs: Hyperplasia, adenoma, carcinoma

BRAD PITT: Pitt-uitary adenoma, MEN1 gene (run-of-the-mill, inactive, turn off)

Question 3

How is MEN-2 different from MEN-1?

Answer 3

Thyroid: Medullary carcinoma

Other endocrine organs: Not much

JOHN CLEESE: Tumor of Cleese cells (bRETon gene, one of a kind, always turned on)

Question 4

Pathologies in MEN-1 Syndrome?

Answer 4

THREE P’s:

Parathyroid hyperplasia

Pancreatic endocrine tumors

Pituitary adenoma

Other stuff (other adenomas, etc.)

Question 5

What are the unique genetic characteristics in MEN-1 Syndrome?

Answer 5

MEN1 gene mutation:

Tumor suppressor gene => Encodes menin (controls cell cycle)

Mutation turns off the gene

Question 6

What are the pathologies present in MEN-2 Syndrome?

Answer 6

Medullary thyroid carcinoma

Pheochromocytoma

Parathyroid hyperplasia

Question 7

What are the unique genetic characteristics in MEN-2 Syndrome?

Answer 7

RET gene mutation

Proto-oncogene => Encodes tyrosine kinase receptor

Mutation turns gene on

Question 8

What is the difference between MEN-2A and MEN-2B?

Answer 8

Both have medullary thyroid carcinoma and RET gene

***But patients with 2B may be Marfanoid