Memory problems- Clincal and management

Question 1

Which is one of the first areas to be affected by Alzheimers disease?

Answer 1

Nucleus basalis of Meynert- main source of ACh for the cortex–> disrupted in AD

Question 2

Which class of medications can be used to slow AD, and how do they work?

Answer 2

Cholinesterase inhibitors

Block acetylcholinesterase in synapse to allow increased ACh

Question 3

Examples of Acetylcholinesterase inhibitors?

Answer 3

Donepezil
Rivastigmine (Also in LBD)
Galantamine

Question 4

Side effects of acetylcholinesterase inhibs?

Answer 4

GI upset
Tiredness
Headache
Sleep disturbance
Bradycardia