Memory

Question 1

What are the three things memory cells require?

Answer 1

• Stemness
• Longevity
• Robustness

Question 2

How are memory B cells created?

Answer 2

Some of the B cells activated in the germinal centres acquire the ability to survive for long periods

Question 3

What type of antibodies do memory B cells produce during the secondary response?

Answer 3

IgG which is a better quality antibody with higher affinity

Question 4

What happens to memory B cells after re-exposure to an antigen memory B cells?

Answer 4

Rapidly proliferate and differentiate into plasma cells that secrete large quantities of high-affinity antibodies

Question 5

Where do memory B cells reside in the body?

Answer 5

Secondary lymphoid organs, bone marrow, and circulation

Question 6

What are the three subsets of memory CD8+ T cells?

Answer 6

• Central memory
• Effector memory
• Resident memory

Question 7

What are central memory CD8+ T cells?

Answer 7

They go to the lymph node and act as a back up system

Question 8

What are effector memory CD8+ T cells?

Answer 8

Circulate in blood and non-lymphoid tissues which can rapidly exert effector functions

Question 9

What are resident memory CD8+ T cells?

Answer 9

Permanently reside in non-lymphoid tissues where initial infection was providing rapid local immune protection at barrier sites

Question 10

How are T cells involved in the production of memory B cells?

Answer 10

Helper T cells provide signals and cytokines that promote B cell proliferation, differentiation, and isotype switching