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Immunology Exam 1 > Memorize 2 > Flashcards

Memorize 2 Flashcards

0
Q

What is CCL2 original name?
What is it’s receptor?
What is it’s function

A

MCP-1
Receptor: CCR2
Transmigration of monocytes

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1
Q

CXCL8- what is it’s original name?
What is it’s receptor?
What is it’s function?

A

IL-8
Receptor- CXCR1 and CXCR2
Function- neutrophil recruitment

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2
Q

What is the original name for CCL19?
What is it’s receptor?
What is it’s function?

A

MIP-3B
CCR7
T cell and DC migration into parafollicular zones in LN’s

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3
Q

What is the original name of CCR21
What is it’s receptor?
What is it’s function?

A

SLC
CCR7
T and DC migration into parafollicular zones in LN’s

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4
Q

What is the original name of CXCL10?
What is its Receptor?
What is it’s function?

A

IP-10
CXCR3 and CXCR3B
Effector T cell recruitment and activation of integrins and cytokines

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5
Q

What is the original name for CCL4?
What is its receptor?
What is its function?

A

MIP-1B
CCR5
Activation of integrins and cytokines

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6
Q

What is the original name of CXCL13?
What is it’s receptor?
What is it’s function?

A

BCA-1
CXCR5
B cell migration into follicles, T follicular helper cell migration into follicles, movement into white pulp

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7
Q

What is the original name of CXCL12?
What is its receptor?
What is its function?

A

SDF1 alpha/beta
CXCR4
Leukocyte recruitment

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8
Q

TLR 2 and 6 recognize what?

A

gram + bacteria- LTA

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9
Q

TLR 4 recognizes what?

A

Gram negative bacteria

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10
Q

TLR 5 recognizes what?

A

Flagellin

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11
Q

TLR 3 recognizes what?

A

dsRNA virus such as Herpes

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12
Q

TLR 7 recognizes what?

A

ssRNA virus such as HIV or Influenza

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13
Q

TLR 9 recognizes what?

A

unmethylated cpg dna sequences

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14
Q

TNF is made by what cells?

what are its functions?

A 
Macrophages and T cells
stimulates hypothalamus to produce fever
stimulates liver to make acute phase protein
causes cachexia 
inflammation
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15
Q

IL-1 is made by what cells?

What are it’s functions?

A

Endothelial cells and macrophages
stimulates hypothalamus to induce fever,
stimulates liver to produce acute phase proteins
causes T cell differentiation
inflammation

16
Q

IL-12 is made by what cells and what is it’s function?

A

produced by macrophages and DC’s

stimulates NK and T cells to produce IFN-gamma and increase cytotoxicity, controls the adaptive T cell response

17
Q

IFN-gamma is produced by what cells and has what functions?

A

NK cell and T helper cells

Defense against viruses, activates macrophages

18
Q

IL-6 is made by what cells and has what functions?

A

made by macrophages,endothelial cells
stimulates the liver to produce acute phase proteins
causes B cells to proliferate antibody producing cells

19
Q

TNF and IL-1 induce expression of what other cytokine from cells?

A

IL-6

Immunology Exam 1 (4 decks)

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