Memorize Flashcards

1
Q

-OH

A

Strong base and strong Nu.

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2
Q

-OR

A

Strong base and strong Nu.

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3
Q

-C(Triple bond)CR

A

Strong base and strong Nu.

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4
Q

-NR2

A

Strong base and strong Nu.

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5
Q

RLi

A

Strong base and strong Nu.

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6
Q

Halides: Cl-, Br-, I-

A

Strong base and weak Nu.

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7
Q

-N3

A

Strong base and weak Nu.

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8
Q

Sulfides

A

Strong base and weak Nu.

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9
Q

-C(Triple bond)N

A

Moderate base and weak Nu.

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10
Q

Tert-butyl Lithium

A

Strong base and Non-Nu.

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11
Q

Potassium Tert-butoxide

A

Strong base and Non-Nu.

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12
Q

LDA, DBU, DBN

A

Strong base and Non-Nu.

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13
Q

H2O and alcohols

A

Weak base and weak Nu.

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14
Q

Strong Nu. Traits

A

Anions with neg. charge. E- density and polarizability. Participate in SN2-type subs.

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15
Q

Weak Nu. Traits

A

Neutral molecules. Participate in SN1-type subs.

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16
Q

Strong Base traits

A

Anions w/ negative charge. Stability determines strength. Participate in E2-type eliminations.

17
Q

Weak Base traits

A

Neutral molecules. Participate in E1-type eliminations. Can occur concurrently with SN1 due to similar conditions.

18
Q

Strong, Non-Nu. Bases

A

Anions that are sterically hindered. ONLY participate in E2.

19
Q

List 4 types of polar protic solvents

A

Water, alcohols, acetic acid, amines

20
Q

List 7 polar aprotic solvents

A

DMF, DMSO, acetonitrile, HMPA, acetone, diethyl ether, THF

21
Q

List 5 good L. G.

A

I-,Br-, Cl-, -OSO2R (sulfonate), H2O

22
Q

List 5 poor L.G.

A

F-, HS-, NC-. HO-, RO-

23
Q

List 3 sulfur containing groups that are very good L.G.

A

Tosylate, mesylate, triflate.