membranes Flashcards

1
Q

flipase

A

p-type

PE and PS inside

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2
Q

flopase

A

moves outside

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3
Q

scramblease

A

moves towards equilibrium

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4
Q

membrane sections of proteins are never disordered because

A

lipid tails are unable to hydrogen bond with the protein backbone or side chains

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5
Q

GLUT1

A

RBCs high affinity

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6
Q

GLUT2

A

general organs

low affinity

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7
Q

GLUT3

A

Brain

high affinity

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8
Q

GLUT4

A

adipose and muscle
insulin dependent
(signals it to the cell surface)

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9
Q

GLUT5

A

intestine (uses 5 in 2 out and SGLT-1 for NA glu in)

FRUCTOSE

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10
Q

symporter

A

2 in same direction

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11
Q

antiporter

A

2 in opposite directions

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12
Q

P-type

A

plasma membrane, must be phosphorylated

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13
Q

F-Type

A

mitochondria H+ pump

Fi and Fo

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14
Q

V-Type

A

Vesicle and same as F-Tpye

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15
Q

ABC

A

Multi-Drug resistance

ATP Binding Cassette

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16
Q

SERCA Pump

A

P-Type
Ca2+ pump
2 per ATP
normal level :SR 500 IC 0.1 EC 1500

17
Q

NaK Pump

A

P-Type

3Na out 2 K in per ATP

18
Q

aquaporin

A

channel

rotates H2O causing specificity and blocking H+

19
Q

which of the following do NOT significantly affect membrane fluidity

A

ratio of glycophospholipid to sphingoipid

20
Q

GLUT1, the most common glucose transporter, would be considered a

A

uniporter

21
Q

The K channel discriminates between K and Na by

A

the carbonyls of the protein backbone replace the hydration sphere of K very precisely

22
Q

Voltage sensor on channels?

A

Helicies

23
Q

Cystic fibrosis - Main defect

A

CFTR Chloride transporter

24
Q

Cystic fibrosis - Test

A

Sweat Test

25
Q

Cystic fibrosis - exact defect

A

PHE 508 deletion

26
Q

Cystic fibrosis - class hierarchy

A

I to VI

worst to least

27
Q

Cystic fibrosis - most common

A

II mis-folded protein

50% functionality is ok