Membrane Transport Flashcards
what are the three main classes of transporters?
channels, transporters and ATP-powered pumps
What ion-channel goes against the normal classification system?
Cystic fibrosis transmembrane conductance regulator (CFTR)
What is an example of a beta-barrel that is not a pore?
OmpX
Where are OmpF and OmpC found?
Outer membrane of porins in E.coli
Which Beta-barrel shows selectivity for solutes?
PhoE
What regulates pore size in gap junctions?
varying connexin mixtures
What disease is caused my a mutation in GLUT1
De Vivo syndrome
What type of transporter are the GLUTs
unitransporters
What are the four ATP-powered pumps?
P class, v-class, F-class and ABC superfamily
What is the difference between the F-class and the rest of the classes?
The F-class does not hydolyse ATP, they are ATP synthases
What are V-class ATPases used for?
To lower the pH in intracellular organelles
What are three examples of ABC transporters?
Maltose transport (MalK), Vitamin B12 transporter (BtuBC) and multidrug resistance protein 1 (Mdr1)
How many subunits make up a pore?
4
What provides the potassium selectivity in KcsA
shorter p-segment
