Membrane Potential Flashcards
What is the RMP Values for neurons , skeletal muscles and cardiac ventricle
Neuron- -70mv
Skeletol muscle and ventricle is -90 mv
Which is the dominant intracellular ion in any cell?
K+
What is restless membrane potential and where it is seen?
RMP Value is unstable or fluctuating
Rmp is oscillating between -60mv to -40mv is known as restless membrane potential.
It is seen in all pacemakers:
-SA node of heart
-interstitial cells of cajal in GIT
-Pre botzinger complex neuron in medulla: pacemaker for respiration
Equilibrium potential is the potential at what part of cell?
Inside the cell
Eqm potential for Na , K, Cl , Ca
Na +60 mv
K -90
E of Cl is equal to RMP of neuron = -70 mv
Ca +130
Equation for calculating EQM potential
E= +/- 61 • logCi/Co or logCo/Ci
Nernst equation for single ion
Gold man hodgkin equation for multiple ion criteria is?
Concentration and permiability of ions for calculating E
How to find driving force and what is driving force
Df = membrane potential- eqm potential
If df is -ve the driving force for cation tend to move inside and anion will be moved outside from the cell
What is gibbs donnan effect and this is effect is exclusively because of what?
Presence of non permeant anions (proteins) on inside cell will affect the distribution (movement) of permiant ions (K and Cl)
Protein anion is the reason for this
RMP IS THE INSIDE NEGATIVITY DUE TO PROTEIN ANION
The plasma protein is responsible for ? Also it is a type of force help in what function
Colloid oncotic pressure and it is a starling force helping in fluid reabsorption
Patch clamp technique?
Used to study current flow across single ion channel
