Membrane Bound Organelles Flashcards
Nucleus
storage and use of genome– inherited genetic disease, enviormentally induced mutations
Nucleolus
Syn of rRNA, regulation of cell cycle– Werner syndrome (premature aging), cancer due to malfunction of cell cycle
rER
binds ribosomes engaged in translating mRNA for proteins , chemical mod of proteins and membrane lipid synthesis– pseudoachondroplasia
plasmamembrane
ion and nutrient transport, recognition of enviormental signal– cystic fibrosis, intestinal malabsorption, LACTOSE INTOLERANCE
sER
lipi and sterior metabolism– hepatic endoplasmic reticular storage disease
Golgi apparatus
Chem modification of proteins, sorting and packaging of proteins,– I-cell disease, polycystic kidney disease
Secretory vesicles
transport and storeage of secrete proteins to plasma mem– Lewy bodies of PARKINGSON’s disease, proinsulin diabetes
Mitochondria
Aerobic energy supply (ATP), initiation of apoptosis– MERRF, MELAS
Endosomes
transport of endocytosed materials, biogenesis of lysosomes – M-6-P recceptor deficiency
Peroxisomes
Oxidative digestion (fatty acids) –Zellweger’s syndrome
Lysosomes
Digestion of macromolecules– lysosomal storage disease
Cytoskeletal elements
Cell motility, cell adhesions, intracellular and extracellular transport, maintenance of cellular skeleton– Immotile cilia syndrome, ALZheimer’s, epidermolysis bullosa
Ribosomes
Syn of protein by translating mRNA sequence– Alzheimer’s, Diamond-blackfan anemia, Ab that act selectively on ribosomes
Glycogen
Short term storage of glucose (liver, skeletal muscle, adipose tissue)– hepatic-hypoglycemic and muscle-energy pathophysiologies
Lipiddroplets
storage of esterified forms of fatty acids (Hi energy storage molecules)– Gaucher’s Niemann-Pick, liver cirrhosis
