Membrane and Action Potentials Flashcards
Saltatory conduction is characteristic of which part of a typical neuron?
Axon
_____ Diameter and ___________ cells will transmit an action potential the fastest.
Large diameter, Myelinated.
A selectivity filter with carbonyl oxygens is associated with what type of ion channels?
Potassium
The resting potential for typical neuron, such as a motor neuron, is best represented by what potential
-90 mV
The axolemma is characterized by the presence of what?
voltage-gated ion channels and the ability to conduct an action potential.
A neuron is characterized by a single ______ that is variable in length.
axon
The _____ is an extension of the cell body and is typically opposite the side of the ________ where the dentrites are located.
axon, cell body.
The axon is an extension of the cell body and is covered by the ____________
axolemma (plasma membrane)
Diffusion potential:
Is caused by an ion concentration difference on either side of a membrane
Nernst Potential
is the diffusion potential level across a membrane that exactly opposes the net diffusion of a particular ion through the membrane.
Nernst Equation
EMF=z(61.5) x Log ([ion]outside/[ion]inside), z= valence of ion
Voltage gated sodium channels have _____ domains and are arranged in a ________ configuration.
four, cylindrical
Define Absolute refractory period:
Period during which a second action potential cannot be elicited even with a strong stimulus. Energy is derived directly from breakdown of ATP
Define Relative refractory period:
Stronger than normal stimulus can cause action potential.
What are factors that affect propagation speed?
Mylination and fiber diameter.
Why do action potentials typically travel in the orthodromic direction?
b/c the signal starts at the axon hillock and the refractory period after depolarization takes a while to reset.
What are the steps in the generation of an action potential on a neuron axon membrane?
Resting stage -90 mV,
depolarization stage: membrane is permeable to sodium. Replolarization stage: K+ channels open more than normal and Na+ close within a few 10,000ths of a second,
Sodium and Potassium conductance.