memantine Flashcards
1
Q
indications (2) - one is to do with dementia, one is to do with MS
A
moderate to severe dementia in AD
oscillopsia (unstable vision) in MS
1
Q
drug class and MOA
A
dopaminergic drug, NMDA (glutamate) receptor antagonist
2
Q
2 severe interactions with memantine - increased risk of CNS toxicity
A
amantadine - caution or avoid
ketamine - avoid
3
Q
interactions with drugs for parkinsons
A
predicted to increase the effects of levodopa, ropinirole, pramiprexole, rotigotine
it is a dopaminergic drug so this makes sense - it is a antagonist at the NMDA receptors
4
Q
cautions (3)
A
- epilepsy, or history, or RF
5
Q
common SE
A
balance impaired
constipation
dizziness
drowsiness
dyspnoea
headache
hypertension
hypersensitivity
