galantamine Flashcards
1
Q
drug class and MOA
A
- Ach-esterase inbibitor
- reversible inhibitor of Ach-esterase and also has nicotinic receptor agonsit properties
2
Q
dose in mild to moderately severe dementia in AD - using IR medicines
A
initally 4mg BD for 4 weeks
increase to 8mg BD for at least 4 weeks
maintenane 8-12mg BD
3
Q
dose in mild to moderately severe dementia in AD - usuing MR caps
A
initally 8mg OD for 4 weeks
increased to 16mg OD for at least 4 weeks
maintenance 16-24mg daily
4
Q
when would you need to avoid galantamine
A
- GI Obstruction
- urinary outflow obstruction
- whilst recovering from bladder surgery
- whilst recovering from GI surgery
5
Q
interactions with galantamine - increased with of Bradycardia with…
A
- betablockers
- anti-arrhythmics
- digoxin
6
Q
patient and carer advice - serious skin reactions
A
Manufacturer recommends that patients are warned of the signs of serious skin reactions; they should be advised to stop taking galantamine immediately and seek medical advice if symptoms occur.
