MELAS

Question 1

What is the inheritance pattern for MELAS?

Answer 1

Mitchondrial

Question 2

What are the clinical manifestations of MELAS?

Answer 2

1. Stroke-liked episodes
2. Basal ganglia infarction
3. Calcifications
4. Diabetes mellitus
5. Thyroid dysfunction
6. Other endocrinologic abnormalities
7. Hearing loss
8. Elevated pyruvate and lactate with increase with exercise