McCune Albright Syndrome

Question 1

What are clinical diagnostic features of McCune Albright?

Answer 1

1. Cafe-au-lait macules (“jagged border”)
2. Polyostotic fibrous dysplasia
3. Any primary endocrinopathy
   a) precocious puberty
   b) hyperthyroidism
   c) growth hormone excess
   d) FGF23-mediate phosphate wasting
   e) neonatal hypercortisolism

Question 2

What is the inheritance pattern of McCune-Albright syndrome?

Answer 2

Sporadic