melanoma

Question 0

melanoma in situ

Answer 0

confined to epidermis
well defined
sun or nonsun exposed

Question 1

risk factors of melanoma

Answer 1

UV
fair skin
genetics: CDKN2A mutation
nevi
xeroderma pigmentosum
immunosuppression

Question 2

lentigo maligna

Answer 2

confined to epidermis
sun exposed skin
illdefined

Question 3

main place in females

Answer 3

back of legs

Question 4

main palce in men

Answer 4

on trunk

Question 5

lentigo maligna

Answer 5

70s, sun damaged skin

Question 6

acral lentingous

Answer 6

dark skin >light skin
50s and 60s
hands and feet digits

Question 7

amelanotic

Answer 7

red color in forgotten melanoma locations-periungual, mucosal, genital, oral, anal-rectal, urethra, eso, ocular

Question 8

pediatric melanoma

Answer 8

3% of pediatric cancers; 90% occur between ages 10-19

Question 9

children with congenital melanocytic nevi

Answer 9

have a 465 fold increased risk of developing melanoma in childhood and adolescence
scalp and neck are most common sites

Question 10

px dependent on site

Answer 10

best to worst

extremities>head neck trunk? volar or sublingual

Question 11

ulceration

Answer 11

worst prognosis

Question 12

breslow thickness

Answer 12

measured from top of granular cell layer to deepest point of tumor penetration

Question 13

lymph nodes

Answer 13

number and burden

Question 14

site of distant mets

Answer 14

worst with visceral vs just skin

Question 15

t classification a

Answer 15

w/o ulceration

Question 16

t calssification b

Answer 16

w/ ulceration

Question 17

stage 1-2 a

Answer 17

excision

Question 18

stage 2b-2c

Answer 18

excision + interferon

Question 19

stage 3

Answer 19

WLE + trial or IFNa or observation

Question 20

stage 4

Answer 20

new and changing

Question 21

iplimumab

Answer 21

+ t cells, not effective, but buys you some time

Question 22

vermurfenib

Answer 22

gives you a 20% increased survival rate