Melanoma Flashcards
1
Q
What is Breslow thickness and why is it important?
A
T0- still in the epidermis
T1- less than 1mm thick
T2- melanoma is between 1.1mm and 2mm thick
T3- melanoma is between 2.1mm and 4mm thick
T4- melanoma is more than 4mm thick
2
Q
What is the pathway from being diagnosed with a melanoma to treatment?
A
- GP referral to Dermatology as 2 week wait
- Biopsy- incisional or excision biopsy
- MDT discussion
- Further surgery
- Investigations
- Referral to oncology
3
Q
Treatment for melanoma summarised
A
Early stages- WLE
More advanced- WLE and SLNB
Advanced or metastatic- palliative treatment
4
Q
How do you identify sentinel lymph node?
A
- Preoperative Lymphoscintigraphy
- Intraoperative Gamma Probe
- Use of Blue Dye
- Sentinel Lymph Node Biopsy (SLNB)
- Dual Modality Approach
5
Q
What is the BRAF mutation?
A
Leads to constitutive activation of the MAPK/ERK signalling pathway, promoting unchecked cell growth and division.
Not genetic
Identified to use more targeted treatment
6
Q
Who is in a skin MDT?
A
- Oncologist
- Surgeon
- Dermatologist
- Plastic surgeon
- Clinical oncologist
- Medical oncologist
- Specialists nurses
- Radiotherapy
- Histologists
7
Q
A
