Meiosis Flashcards

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1
Q

Classifications of cells present in sexually reproductive organisms

A

Somatic cells: Diploid number of chromosomes
Gametes: Haploid number of chromosomes (sperm and ova)

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2
Q

What are the results of meiosis?

A

Reduction of chromosome number
Segregation of alleles
Random assortment of homologs
Shuffling the genetic material by crossing over

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3
Q

Meiosis name in males and females

A

Males = Spermatogenesis (production of sperm in the seminiferous tubules of the testes)
Females = Oogenesis (production of ova in the ovaries)

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4
Q

Process of spermatogenesis

A

Stage 1: Division of germline epithelium by mitosis into spermatogonia
Stage 2: Spermatogonia undergo growth
Stage 3: Two meiotic divisions of spermatocytes produces four daughter cells
Stage 4: Haploid cells differentiate to form sperm cells
Stage 5: Sperm cells nourished by Sertoli cells

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5
Q

Process of oogenesis

A

Stage 1: Start at fetal development with oogonia forming by mitosis
Stage 2: Oogonia start meiosis but the process is arrested at prophase I
Stage 3: After puberty, follicles continue developing each month through FSH secretion
Stage 4: Follicles complete meiotic division forming two unequally sized cells. Polar body is degraded and secondary oocyte forms from larger cell
Stage 5: Secondary oocyte begins second meiotic division which is arrested at prophase II until fertilisation
Stage 6: It is released from the ovary (ruptured follicle develops into corpus luteum) and, if fertilisation occurs, will complete meiosis
Stage 7: The second meiotic division will produce an ovum and a second polar body

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6
Q

What are the stages of meiosis?

A

Meiosis I
Meiosis II

Meiosis II has no interphase

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7
Q

What are the events of interphase I?

A

Chromosomes replicated during S phase
Duplicated chromosomes contain two identical sister chromatids attached at the centromere
Centriole pairs replicate

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8
Q

What occurs during the first meiosis division?

A

Cell division reduces the number of chromosomes by half
Stages:
* Prophase I
* Metaphase I
* Anaphase I
* Telophase I

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9
Q

What are the five stages of prophase I

A

Leptotene
Zygotene
Pachytene
Diplotene
Diakinesis

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10
Q

What occurs during leptotene

First stage of prophase I

A

Chromosomes condense

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11
Q

What occurs during zygotene?

Second stage of prophase I

A

Synapsis occurs (homologous chromosomes pairing to form a tetrad along their length)

Tetrad = two chomosomes/four non-sister chromatids

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12
Q

What occurs during pachytene?

Third stage of prophase I

A

Crossing over occurs in syneptonemal complexes

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13
Q

What occurs during diplotene?

Fourth stage of prophase I

A

Homologous recombination (chiasmata formed by migration of DNA strands between DNA molecules in a reciprocal manner)

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14
Q

What occurs during diakinesis?

Fifth stage of prophase I

A

Terminalisation of chiasmata
Chromosomes reach maximal condensation

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15
Q

What occurs during metaphase I?

A

Tetrads align along the metaphase plate
Random orientation of homologous pairs to the poles of the cell are random

Metaphase I is the shortest phase of meiosis I

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16
Q

What occurs during anaphase I?

A

Homologous chromosomes move towards the poles

Sister chromosomes remain attached at the centromeres

17
Q

What occurs during telophase I?

A

Each pole now has a haploid number of chromosomes

Cytokinesis occurs subsequent to telophase forming two daughter cells

18
Q

Prophase II and Metaphase II

A

Same as in mitosis

19
Q

What occurs during anaphase II?

A

Sister chromatid separate

20
Q

What occurs during telophase II?

A

Nuclei form

Cytokinesis occurs subsequent to telophase forming four haploid cells

21
Q

What is non-disjunction?

A

Failure of homologous chromosomes or sister chromatids to separate during meiosis

22
Q

What are the two types of non-disjunction?

A

Monosomy (one chromosome)
Trisomy (three chromosomes)

23
Q

Common non-disjunction disorders

A

Trisomy 18 - Edward’s syndrome
Trisomy 21 - Down’s syndrome
Trisomy 23 - Kleinfelter’s syndrome (XXY)
Monosomy 23 - Turner’s syndrome