Meglitinides Flashcards
1
Q
Give examples of the meglitinides.
A
Nateglinide (only with metformin) and repaglinide.
2
Q
What is the mechanism of action of the meglitinides?
A
Rapid acting secretagogues (promote insulin secretion) from the pancreas when blood glucose levels are at their highest and not at fasting levels. Short duration of action.
3
Q
What are the side effects of the meglitinides?
A
Hypos, hypersensitivity reactions (pruritis, rashes), abdominal pain, diarrhea, constipation, nausea, vomiting.
4
Q
Which side effect has only been reported with the use of repaglinide?
A
Visual disturbances.
5
Q
In what circumstances is repaglinide recommended by NICE?
A
If metformin is contraindicated.
6
Q
When should meglitinides be taken?
A
30 minutes before main meals due to short duration of action.
