Meds for ACS Flashcards
Nitro effect O2 S and D
Venodilator. Decreases preload and contractility by starlings law
Vasodilator at higher dose decreases afterload
forms free radicals NO (relaxes smooth muscles). Dilates coronary arteries and improves perfusion
Avoid viagra
ASA
platelet inhibitor
Blocks formation of Thrombin A. inhibits platelet aggregation
Decreases blood viscosity and decreases afterload
- most important for improving MI mortality**
Clopidogel
Platelet inhibitor
inhibit platelet activation/aggregation
decrease blood viscosity/decrease afterload
can cause brady dysrhythmias
Ticagrelor
Platelet inhibitor
More rapid onset than plavix. more pronounces platelet inhibition
decrease blood viscosity /decrease afterload
Heparin / enoxaparin/ dalteparin
Antithrombin/anticoagulant
prevent blood clots from forming. Inactivate thrombin, prevent conversion of fibrinogen to fibrin.
decrease blood viscosity, decrease afterload, prevent thrombus enlargement
Apixaban/ Rivaroxaban
Oral anticoagulants (NOVEL OACs)
Direct thrombus inhibitors. Oral factor Xa inhibitors
decrease blood viscosity, decrease afterload, prevent thrombus enlargement
Morphine
Analgesic
Mimic endogenous endorphins–> vasodilate
Decrease O2 demand
Lipitor / simvastatin /atorvastatin
anti-cholesterol
prevent blockage of arteries
decrease blood viscosity, decrease afterload
Metoprolol,
Carvedilol
M Beta 1 C Beta 1, 2 and alpha 1
Blocks stimulatory effects of catecholamines on B1 B2 cells. - inotrope, chronotrope.
Reduce vent remodeling
(avoid cardiogenic shock, hypotension, recent cocaine)
decrease HR, decrease O2 demand, decrease contractility, decrease demand during isovolumetric contraction
Ramipril/captopril
Candesartan
ACEI / ARB
Prevent conversion of angiotensin 1 to 2 and blocks receptors for angiotensin 2
Decreases afterload and decreases myocardial demand
Tenecteplase (TNK) / Alteplase / Reteplase (RPA)
Fibrinolytic
Converts plasinogen to plasmin, enz responsible for degradation of fibrin clots
Decreases viscosity
