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Immunology > Meds > Flashcards

Meds Flashcards

1
Q

Cyclosporine

A

Calcineurin inhibitor that binds cyclophilin

Blocks T-cell activation by preventing IL-2 transcription

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2
Q

Tacrolimus

A

Calcineurin inhibitor that binds cyclophilin

Blocks T-cell activation by preventing IL-2 transcription

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3
Q

Sirolimus (Rapamycin)

A

mTOR inhibitor, binds FKBP

Blocks T-cell activation and B-cell differentiation by preventing response to IL-2

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4
Q

Basiliximab

A

Monoclonal antibody that blocks IL-2R

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5
Q

Azathioprine

A

Antimetabolite precursor of 6-mercaptopurine

Inhibits lymphocyte proliferation by blocking nucleotide synthesis

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6
Q

Mycophenolate mofetil

A

Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells

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7
Q

Glucocorticoids

A

Inhibit NFkB
Suppress both B and T cell function by decreased transcription of many cytokines
Induce T cell apoptosis

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8
Q

Alemtuzumab

A

anti-CD52 antibody used in CLL

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9
Q

Bevacizumab

A

anti-VEGF antibody used for colorectal cancer, renal cell carcinoma, non-small cel lung cancer

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10
Q

Cetuximab

A

anti-EGFR antibody

Used for stage IV colorectal cancer, head and neck cancer

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11
Q

Rituximab

A

anti-CD20 antibody

Used for B cell non-Hodgkin lymphoma, CLL, RA, ITP, multiple sclerosis

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12
Q

Trastuzumab

A

anti-HER2 antibody

Used for breast cancer, gastric cancer

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13
Q

Adalimumab

A

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

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14
Q

Certolizumab

A

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

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15
Q

Golimumab

A

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

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16
Q

Infliximab

A

anti-soluble TNF-alpha

used for IBD, RA, AS, psoriasis

17
Q

Daclizumab

A

anti-CD25 (part of IL-2 receptor)

Used for relapsing multiple sclerosis

18
Q

Eculizumab

A

anti-complement protein C5 antibody

Used for paroxysmal nocturnal hemoglobinuria

19
Q

Natalizumab

A

anti-alpha 4 integrin antibody

Used for MS, Crohn’s

20
Q

Ustekinumab

A

anti-IL 12/IL-23 antibody

Used for psoriasis and psoriatic arthritis

21
Q

Abciximab

A

anti-platelet glycoproteins IIb/IIIa antibody

Used for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

22
Q

Denosumab

A

anti-RANKL antibody

Used for osteoporosis to inhibit osteoclast maturation

23
Q

Anti-digoxin immune Fab

A

anti-digoxin antibody

Used as antidote for digoxin toxicity

24
Q

Omalizumab

A

anti-IgE antibody
used for refractory allergic asthma
used to prevent IgE binding to FceRI

25
Q

Palivizumab

A

anti-RSV F protein

Used for RSV prophylaxis for high-risk infants

Immunology (6 decks)

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