Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-presynaptic voltage-gated calcium channel

Answer 2

Lambert-Eaton myasthenic syndrome

Question 3

Anti-beta2 glycoprotein

Answer 3

Antipohspholipid syndrome (APS)

Question 4

Antinuclear (ANA)

Answer 4

Nonspecific screening antibody, often associated with SLE

Question 5

Anticardiolipin, lupus anticoagulant

Answer 5

SLE, APS

Question 6

Anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

Anti-histone

Answer 7

Drug-induced lupus

Question 8

Anti-U1 RNP

Answer 8

Mixed connective tissue disorder

Question 9

Rheumatoid factor (IgM against IgG Fc region), anti-CCP

Answer 9

Rheumatoid arthritis

Question 10

Anti-Ro/SSSA, Anti-La/SSB

Answer 10

Sjogren syndrome

Question 11

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 11

Scleroderma (diffuse)

Question 12

Anticentromere

Answer 12

Limited Scleroderma (CREST syndrome)

Question 13

Antisynthetase (eg anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2)

Answer 13

Polymyositis, dermatomyositis

Question 14

Antimitochondrial primary biliary cirrhosis

Answer 14

Primary biliary cholangitis

Question 15

Anti-smooth muscle

Answer 15

Autoimmune hepatitis type 1

Question 16

MPO-ANCA/p-ANCA

Answer 16

Microscopic polyangiitis
eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
ulcerative colitis

Question 17

PR3-ANCA/c-ANCA

Answer 17

Granulomatosis with polyangiitis (Wegener)

Question 18

Anti-phospholipase A2 receptor

Answer 18

Primary membranous nephropathy

Question 19

Anti-hemidesmosome

Answer 19

Bullous pemphigoid

Question 20

Anti-desmoglein (anti-desmosome)

Answer 20

Pemphigus vulgaris

Question 21

Antimicrosomal, antithyroglobulin, antithyroid peroxidase

Answer 21

Hashimoto thyroiditis

Question 22

Anti-TSH receptor

Answer 22

Graves disease

Question 23

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide

Answer 23

Celiac disease

Question 24

Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

Answer 24

T1DM

Question 25

Antiparietal cell, anti-intrinsic factor

Answer 25

Pernicious anemia

Question 26

Anti-glomerular basement membrane

Answer 26

Goodpasture syndrome