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Immunology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-presynaptic voltage-gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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3
Q

Anti-beta2 glycoprotein

A

Antipohspholipid syndrome (APS)

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4
Q

Antinuclear (ANA)

A

Nonspecific screening antibody, often associated with SLE

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5
Q

Anticardiolipin, lupus anticoagulant

A

SLE, APS

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6
Q

Anti-dsDNA, anti-Smith

A

SLE

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7
Q

Anti-histone

A

Drug-induced lupus

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8
Q

Anti-U1 RNP

A

Mixed connective tissue disorder

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9
Q

Rheumatoid factor (IgM against IgG Fc region), anti-CCP

A

Rheumatoid arthritis

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10
Q

Anti-Ro/SSSA, Anti-La/SSB

A

Sjogren syndrome

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11
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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12
Q

Anticentromere

A

Limited Scleroderma (CREST syndrome)

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13
Q

Antisynthetase (eg anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2)

A

Polymyositis, dermatomyositis

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14
Q

Antimitochondrial primary biliary cirrhosis

A

Primary biliary cholangitis

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15
Q

Anti-smooth muscle

A

Autoimmune hepatitis type 1

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16
Q

MPO-ANCA/p-ANCA

A

Microscopic polyangiitis
eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
ulcerative colitis

17
Q

PR3-ANCA/c-ANCA

A

Granulomatosis with polyangiitis (Wegener)

18
Q

Anti-phospholipase A2 receptor

A

Primary membranous nephropathy

19
Q

Anti-hemidesmosome

A

Bullous pemphigoid

20
Q

Anti-desmoglein (anti-desmosome)

A

Pemphigus vulgaris

21
Q

Antimicrosomal, antithyroglobulin, antithyroid peroxidase

A

Hashimoto thyroiditis

22
Q

Anti-TSH receptor

A

Graves disease

23
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide

A

Celiac disease

24
Q

Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

A

T1DM

25
Q

Antiparietal cell, anti-intrinsic factor

A

Pernicious anemia

26
Q

Anti-glomerular basement membrane

A

Goodpasture syndrome

Immunology (6 decks)

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