Meds

Question 1

Multiple Myeloma

Answer 1

dexamethasone plus thalidomide or lanalidomide -> autologous stem cell transplant

Question 2

Multiple Myeloma >75yo, not a stem cell transplant candidate

Answer 2

melphan plus prednisone

or bortezomib

Question 3

CML

Answer 3

imatinib, desatinib, nilotinib (to eradicate the philadelphia chromosome) for life
hydroxyurea can be palliative

Question 4

Thrombocytosis

Answer 4

don’t have to treat if asymptomatic

hydroxyurea, anagrelide, interferon alpha plus low dose asprin

Question 5

MDS patients with 5q syndrome

Answer 5

lenalidomide

Question 6

CLL in younger patients

Answer 6

treat stage III/IV

fludarabine plus cyclophosphamide and rituximab

Question 7

CLL in older patients

Answer 7

ibrutinib (used to be chlorambucil)

Question 8

Hairy Cell Lymphoma

Answer 8

cladribine

Question 9

AML

Answer 9

cytarabine and anthracycline
ATRA for APML (give before Dx confirmed w FISH)
gemtuzumab ozagamicin for older, CD33+ patients

Question 10

Paroxysmal Nocturnal Hemoglobinuria

Answer 10

if symptomatic: eculizumab

Question 11

Aplastic Anemia

Answer 11

stem cell transplant if

Question 12

Hemolytic Anemia

Answer 12

folic acid supplements for everyone!

Question 13

Cervical Ca Stage II-IV

Answer 13

XRT and cisplatin

Question 14

Ovarian Ca

Answer 14

surgery plus platinum and paclitaxel

Question 15

Hormone refractory prostate Ca

Answer 15

docetaxel

Question 16

Testicular Ca

Answer 16

cisplatin

Question 17

Colon Ca

Answer 17

FOLFOX (5-FU, leukovorin, oxaliplatin), can add bevacizumab

Question 18

Pancreatic Ca

Answer 18

5-FU (w XRT), gemcitabine

Question 19

RCC

Answer 19

sunatinib, sorafenib, paxopanib, temsirolimus, high dose IL2

Question 20

Hodgkin’s lymphoma

Answer 20

adriamycin, bleomycin, vinblastine, dacarbazine

Question 21

Follicular lymphoma

Answer 21

rituximab +/- chemo

Question 22

DLBCL

Answer 22

R-CHOP = rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone

Question 23

APML

Answer 23

ATRA (w presumptive Dx, don’t wait for FISH)

Question 24

Burkitt lymphoma

Answer 24

R-hyper-CVAD: rituximab, rapidly cycled cyclophosphamide, vincristine, doxorubicin, dexamethasone

Question 25

High grade poorly differentiated neuroendocrine tumor

Answer 25

Platinum based chemo

Question 26

GIST w high risk for recurrence

Answer 26

imatinib

Question 27

Squamous and non-squamous non small cell lung cancer failing platinum-based chemo

Answer 27

nivolumab (PD-1 inhibitor)

Question 28

Stage I, II, or III anal SCC

Answer 28

radiation plus chemo (mitomycin and 5-FU)

Question 29

Prostate Ca bone mets

Answer 29

radium-223