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Biochem > medorg > Flashcards

medorg Flashcards

cns anti depressants

1
Q

1,3,7 - Trimethylxanthines

A

caffeine

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2
Q

1,3 - Dimethylxanthines

A

theophylline

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3
Q

3,7 - Dimethylxanthines

A

Theobromine

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4
Q

pramines

A

Dibenzazepine

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5
Q
A
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6
Q

NSRI with chlorine at c3

A

clomipramine

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6
Q

prototype of NSRI

A

imipramine

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6
Q

only SNRI in dibenzazepine “pramine”

A

desipramine

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7
Q

increases affinity to net and sert

A

c3-x

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8
Q

triptyline

A

dibenzocycloheptadiene

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9
Q

npad

A

nortriptyline, protriptyline, amitriptyline, doxepine

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10
Q

nsri have oxygen at c11

A

doxepine

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11
Q

snri agent kay dibenzocycloheptadiene

A

np

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12
Q

nsri kay dibenzocycloheptadiene

A

amitriptyline AND doxepine

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13
Q

e-isomer selectively inhibits net, and s-isomer inhibits sert

A

doxepine

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14
Q

have propylene moiety

A

nortriptyline and amitriptyline

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15
Q

non tca that uses r- enantiomer is more active

A

atomoxetine

16
Q

only snri that na dicyclic

A

atomoxetine

17
Q

inhibits sert and have high affinity and activity for SERT

A

ssri (selective serotonin reuptake inhibitor)

18
Q

ssri that has more active s-isomer

A

escitaloprami

19
Q

r isomer of escitalopram

A

citalopram

20
Q

fluoxetine r isomer is____: s-isomer is____

A

r isomer is MORE POTENT : s-isomer is HIGHER AFFINITY TO SERT

21
Q

1s, 4r isomer is more active for sert inhibition

A

sertraline

22
Q

3s,4r isomer more active for sert inhibition

A

paroxetine

23
Q

e isomer more active for sert inhibition

A

fluvoxamine

24
Q

used for deamination of amine

A

mao (monoamine oxidase)

25
Q

substrate of MAO-A

A

5-HT (serotonin)

26
Q

substrate of MAO-B

A

NE, DA

27
Q

pmst

A

phenelzine, moclobemide, selegiline, tranylcypromine

28
Q

reversible inhibitor of mao-a, w/o hypertensive crisis

A

moclobemide

29
Q

non selective irreversible

A

phenelzine

30
Q

irreversible inhibitor of mao-b

A

selegiline

31
Q

5-HT1A and SERT inhibitor

A

vortioxetine

32
Q

partial serotonin agonist

A

vilazodone

33
Q

VVAT

A

vortioxetine, vilazodone, Aripiprazole, Trazodone

34
Q

lipophilic drug PRECURSOR

A

levadopa

35
Q

COMT inhibitors

A

entaCAPONE, tolCAPONE

36
Q

DA Agonist and reuptake inhibitor

A

amantadine

37
Q

da agonist

A

bromocriptine

38
Q

anticholinergics (tremor management)

A

benztropine, biperiden,

39
Q

mao-b inhibitors w/o hypertensive crisis

A

seleGILINE, raGILINE

Biochem (8 decks)

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