Medium Vessel Vasculitis

Question 1

What are the most important medium vessel vasculitis?

Answer 1

Polyarteritis nodosa PAN
Kawasaki disease
Buerger disease

Question 2

Which vessels are involved in PAN?

Answer 2

PAN: PULMONARY ARTERY NEVER (lung spares)
-Mesentric vessels
-Renal artery
- Any organ below the diaphragm

Question 3

What are the clinical features of PAN?

Answer 3

-Abdominal pain and melena (due to mesentric vessels)
-Hypertension (due to renal artery)
-Neurological disturbance
-SKIN LESIONS

Question 4

How do you diagnose PAN?

Answer 4

-Transmural inflammation (PAN=Pancyto=all)
-lesions of various stages (fibrinoid necrosis, healed woth fibrosis)
- STRING OF PEARL appearance (PAN SOP)
-Hepatitis B surface antigen (PAN’s BAG)

Question 5

Treatment of PAN…

Answer 5

Corticosteroids
Cyclophosphamide (spamming cyclops poly times)

Question 6

Which vessel is involved in kawasaki disease?

Answer 6

Coronary artery

Question 7

Who is most likely to be affected with kawasaki?

Answer 7

Asians younger than 4yrs (3 asian babies on kawasaki motor)

Question 8

What are the clinical features of kawasaki

Answer 8

CRASH and burn:-
Conjunctivitis
Rash on skin
Adenopathy cervical
Strawberry tongue
Hands and feet changes (pain fever erythema)
Burn to remember its an inflammation

Question 9

What is the treatment of kawasaki?

Answer 9

Corticosteroids and IV imunoglobulins (pole thingy next to motor)

Question 10

Complications of kawasaki disease…

Answer 10

Ruptured aneurysm
MI
thrombosis