Medicines of Tomorrow Flashcards
Final prep
Examples of good bacteria?
E. Coli
Lactobacillus
Difference between gram-positive and gram-negative?
Gram-positive have no outer lipid membrane and a thick peptidoglycan layer. Stain purple
Gram-negative have an outer membrane and a thinner peptidoglycan layer. Stain red
Three reasons bacteria are essential to us?
Protect us from pathogens on skin
Help alert immune response
Break down food in digestive system
What is the Therapeutic index?
A measurement on the relative safety of a drug. A ratio between the therapeutic effect and toxic dose
What is the Kirby-Bauer disk diffusion test?
A susceptibility test to measure the sensitivity of bacteria to an antibiotic by determining the zone of inhibition on a growth media
Why would you add an acidic compound to do a liquid-liquid extraction?
To protonate a base, making it move into the aqueous layer
Why would you add a basic compound to a liquid-liquid extraction?
To deprotonate an acid and make it move into the aqueous layer
1-octanol, polar or non-polar?
CH3-CH2-CH2-CH2-CH2-CH2-CH2-CH2-OH
Non-polar
Polar end not large enough to counteract non-polar end
Chemical shift value 3 - 5?
Halogens
Chemical shift value 7?
Aromatics
Chemical shift value 9 - 12?
Carboxyl or Aldehydes