Medicines and Drugs - D9 - Drug Design Flashcards
Many medicines and drugs are fairly complex organic molecules with low _________.
Polarity.
To increase the solubility so they can be transported easily around the body, most medicines are administered as an ___________.
Ionic Salt.
What is combiatorial chemistry?
A variety of techniques and technologies for creating a large number of molecules and testing them quickly for desirable biological properties.
What is parallel synthesis?
The creation of smaller, more focused compound libraries using robotics.
What is meant by in vitro?
Performed in a test tube.
What is meant by in silico?
Performed on a computer or a computer simulation.
What is meant by in vivo?
Performed in a human body.
What are inhibitors?
Molecules that are capable of binding or interfering with the active site of a protein.
What is a lead compound?
The main chemical compound of a potential new drug
Describe combinatorial synthesis
A way of synthesising potential new drugs by reacting a set of starting materials (lead compounds) in all possible combinations with the help of modern technologies, thus creating large libraries of different compounds
What are enantiomers?
-
What animal are drugs tested on?
Rats, monkeys, mammals in general.
What is the function of chiral auxiliaries?
-
In a drug trial, 50% of the test population get to receive the drug. What do the other 50% of the test populations get?
Placebo drugs. (for the IB exams).
What does auxiliary mean?
Helping hand
