Medicinal Chemistry Introduction Annabelle Flashcards
1
Q
The chemical structure of a drug dictates…
A
Bioactivity- pharmacodynamics/kinetics
2
Q
Medicinal chemists can be involved in (4)
A
synthesis
drug development
physiochemical properties
bioassay
3
Q
Chemical structure and name:
common name endings doesn’t necessarily imply — and — similarity.
Same carbon framework doesn’t necessarily imply the same — properties
A
structural
medicinal
biological
4
Q
How are drugs grouped together? (5)
A
chemical structure or name illegality, toxcity, dependency source effect on body molecular targets
5
Q
5 molecular targets for drugs
A
enzymes receptors DNA/RNA ion carriers ion channels
6
Q
The drug development journey (6)
A
Identify the target Find the lead develop structurally related analogues Study the SARs Bioassay and refine structure Clinical trials
