Med Chem 1

Question 1

5 bonds between drug and target:

Answer 1

Hydrogen bonds
Ionic bonds
Van-der-Waals interactions
dipole-dipole interactions
Ion-dipole interactions

Question 2

Physiochemical properties of drugs 4:

Answer 2

Molecular weight
Hydrophobicity of Molecule
Polar surface areas
Number of HBD and HBA

Question 3

Nutrient broth can generate which part of the penicillin molecule?
Which other part has to be made seperately?

Answer 3

6-aminopenicillianic acid

Acyl side chain

Question 4

The side chain on penicillins varies with what variation in fermentation?

Answer 4

Carboxylic acid used.

Question 5

Nitrogen is —, therefore prefers the bond angle of –

Answer 5

tetrahedral

109

Question 6

Penicililin G:  
Is active against which bacteria?
Has a limited range of what?
Is sensitive to which bacterial enzyme?
Is inactive against

Answer 6

Gram positive
activity
B-lactamase
staphylococci